Cell biology

Process (computing)

Engineering

Polymer chemistry

Biology

Biomedical engineering

Materials science

Cell encapsulation

Operating system

Tissue engineering

Regeneration (biology)

Computer science

Nanotechnology

Self-healing hydrogels

Journal of Tissue Engineering

Hydrogels are three-dimensional polymeric networks filled with water and mimic tissue environments. Therefore, they are considered optimal to deliver cells and engineer damaged tissues. The hydrogel networks have been significantly modified to endow biochemical functionality with adhesive ligands, growth factors, or degradable sites that are helpful to drive proper cell functions. Recently, some of the biophysical properties of hydrogels have emerged as key players in dictating cell fate. Beyond static stiffness, time-dependent stress/strain changes in the interaction with cells and the cell-mediated degradation and matrix synthesis have been demonstrated to shape cell status and tissue repair process. We highlight here the emerging biophysical properties of hydrogels that can motivate tissue engineers to design and develop hydrogels optimally for tissue regeneration.

Emerging properties of hydrogels in tissue engineering