Hypoxic Ischemic Encephalopathy

Pediatrics

Cerebral palsy

Encephalopathy

Political science

Neonatal encephalopathy

Physical therapy

Meta-analysis

Internal medicine

MEDLINE

Medicine

Hypothermia

Early Human Development

Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing 50% of those with HIE, are perceived as low risk and are currently not eligible for TH [1]. This review examines the available evidence of outcome in term infants with mild HIE.Medline, Embase and Cochrane Clinical Trials databases were searched in March 2017. Studies with well-defined HIE grading at birth and standardised neurodevelopmental assessment at ≥18 months were included. Abnormal outcome was defined as death, cerebral palsy or standardised neurodevelopmental test score more than 1 standard deviation below the mean.Twenty studies were included. Abnormal outcome was reported in 86/341 (25%) of infants. There was insufficient evidence to examine the effect of TH on outcome.A significant proportion of infants with mild HIE have abnormal outcome at follow up.

Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - A systematic review