Recognition of RNA N 6 -methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Volume: 20, Issue: 3, Pages: 285 - 295
Published: Feb 23, 2018
Abstract
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence. In contrast to the...
Paper Details
Title
Recognition of RNA N 6 -methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Published Date
Feb 23, 2018
Volume
20
Issue
3
Pages
285 - 295
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.