Intensive care medicine

Purine

Hyperuricemia

Gout

Febuxostat

Xanthine oxidase inhibitor

Biochemistry

Allopurinol

Enzyme

Internal medicine

Pharmacology

Medicine

Chemistry

Uric acid

Xanthine oxidase

New England Journal of Medicine

Cardiovascular risk is increased in patients with gout. We compared cardiovascular outcomes associated with febuxostat, a nonpurine xanthine oxidase inhibitor, with those associated with allopurinol, a purine base analogue xanthine oxidase inhibitor, in patients with gout and cardiovascular disease.

Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout