Nanogel

Biotechnology

Nanotechnology

In vivo

Membrane

Biology

Biomedical engineering

Surgery

Dermatology

Methyl cellulose

Chemistry

Materials science

Immunology

Ex vivo

Irritation

Cellulose

Curcumin

Drug delivery

Wound healing

Skin irritation

Permeation

Biochemistry

Medicine

International Journal of Polymeric Materials

The objective of the present investigation was to formulate curcumin loaded fish scale collagen (FSC)-hydroxypropyl methyl cellulose (HPMC K100) nanogel (CNG) for wound healing application. The curcumin nanoemulsion was prepared, characterized and loaded in FSC-HPMC nanogel. The nanogel was evaluated for ex-vivo permeation, in-vivo, skin irritation, and stability study. Ex-vivo permeation study demonstrated that CNG prolonged release and exhibited higher percent contraction value of wound compared to other formulations. In skin irritation study, formulation produced the score of less than 2 compared to control. It concluded that curcumin loaded FSC-HPMC nanogel could be prepared for wound healing applications.

Curcumin loaded fish scale collagen-HPMC nanogel for wound healing application: <i>Ex-vivo</i> and <i>In-vivo</i> evaluation

Curcumin loaded fish scale collagen-HPMC nanogel for wound healing application: Ex-vivo and In-vivo evaluation