Internal medicine

Pathology

Neuroscience

Parkinsonism

Enteric nervous system

Disease

Vagus nerve

Alpha-synuclein

Central nervous system

Nervous system

Brainstem

Blood pressure

Biology

Stimulation

Autonomic nervous system

Parkinson's disease

Heart rate

Dorsal motor nucleus

Peripheral nervous system

Medicine

Neurobiology of Disease

Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson's disease. Aggregated α-syn is present in spor…

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology