Internal medicine

AMPK

Myocardial infarction

Endocrinology

Cardiology

Kinase

Chemistry

Protein kinase A

Biochemistry

Medicine

Journal of Molecular and Cellular Cardiology

We have revealed that a novel stress-inducible protein, Sestrin2, declines in the heart with aging. Moreover, there is an interaction between Sestrin2 and energy sensor AMPK in the heart in response to ischemic stress. The objective of this study is to determine whether Sestrin2-AMPK complex modulates PGC-1α in the heart and protects the heart from ischemic insults. In order to characterize the role of cardiac Sestrin2-AMPK signaling cascade in aging, C57BL/6 wild type young mice (3–4months), aged mice (24–26months) and young Sestrin2 KO mice were subjected to left anterior descending coronary artery occlusion for in vivo regional ischemia.

Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway