Internal medicine

Pharmacist

Intervention (counseling)

Cost-minimization analysis

Family medicine

Biology

Microbiology

Pharmacy

Nursing

Antimicrobial

Medicine

Clinical Epidemiology and Global Health

Antimicrobial agents are used to treat the infectious diseases which and has become a routine milieu. Prescribing intravenous (IV) antimicrobial agents are needed for abruptly subduing the infectious stage and will leads to decrease the infectious severity of the patient. The cost minimization Analysis involved monitoring the IV to oral conversions carried out in General Medicine department as a part of Antimicrobial stewardship Programme (ASP) for initial 3 months followed by feedbacks, guideline preparation and CME programs as intervention. This was followed up by a post-intervention audit to assess the effectiveness of the interventions performed. An aggregate of 102 subjects were enrolled in the study and quantitative use of the parenteral AMA was found to be significantly reduced in the post-interventional phase in comparison to the pre-interventional phase (p = 0.028) and the conversion per patient rate is also increased (p = 0.0001). Similar reductions were also achieved by the intervention in the duration required for oral conversions, average difference is 2 days (p = 0.000). 19.5% reduction in the usage of cost of antibiotics is achieved with a 0.010076DDD/100 Bed days difference to the control population. The study was successful in increasing the conversion rate which clearly implicated the acceptance of guideline. The recommendations of the clinical pharmacist were successful in reducing both the length of stay and duration of parenteral therapy, there in reducing the consumption and cost of antimicrobial therapy. The cost minimizations were found by IV to oral conversion of antibiotics without any change in the treatment outcome.

Cost minimization analysis on IV to oral conversion of antimicrobial agent by the clinical pharmacist intervention