Physics

Pathology

Balanites aegyptiaca

Biology

Astronomy

Chemistry

Alternative medicine

Antioxidant

Polar

Botany

Antioxidant capacity

Biochemistry

Traditional medicine

Medicine

Asian Pacific Journal of Tropical Disease

Objective: To investigate the biological activities of polar and non-polar extracts of Balanites aegyptiaca fruits.Methods: Antihyperglycemic activity using alloxan induced diabetic rats was evaluated.In vitro cytotoxicity against human carcinoma cell lines activity in addition to antioxidant and antitrematodal effects were investigated.Phytochemicals were determined using chromatographic and spectral analyses including TLC, GC and LC/MS/MS methods. Results:The reduction in blood glucose level reached 64.13%, 69.07%and 77.01%for hexane, chloroform and methanol extract, respectively.Isolated organs and histopathological examination illustrated improvement in treated animal's pancreas which is the master gland in controlling glucose level.The highest in vitro free radical scavenging capacity was achieved by chloroform extract (75.72%).Meanwhile, hexane and methanol extracts exhibited 44.01%and 41.77% scavenging capacity, respectively.Cytotoxic activity against human carcinoma cell lines illustrated efficacious influence against brain, liver, lung, breast and lymphoblastic leukemia cell lines.Brain cell line was the most susceptible cell line by both chloroform and methanol extracts.In vitro antitrematodal effectiveness showed that 100% mortality of Schistosoma worms was induced at the 3rd and 5th days for methanol and chloroform extracts.Meanwhile, both extracts exhibited antifasciolosis activity with LC 50 of 63.19 and 55.15 mg/L, respectively. Conclusions:The current results illustrated that Balanites aegyptiaca phytochemicals induced potent hypoglycemic activity and potent to moderate antioxidant and cytotoxic effects.Chloroform and methanol extracts were found to have antitrematodal efficacy against Schistosoma mansoni and Fasciola gigantica hepatic worms.

Antidiabetic, cytotoxic, antioxidant and antitrematodal medicinal efficacy of polar and non-polar phytochemicals of Balanites aegyptiaca Del.