Internal medicine

Depression (economics)

Irritable bowel syndrome

Quality of life (healthcare)

Population

Rating scale

Gastroenterology

Psychiatry

Macroeconomics

Nursing

Developmental psychology

Psychology

Economics

Anxiety

Abdominal pain

Cohort

Medicine

Environmental health

Neurogastroenterology & Motility

Background The Rome criteria for irritable bowel syndrome ( IBS ) have been revised and are expected to apply only to the subset of Rome III IBS subjects with abdominal pain as predominant symptom, occurring at least once a week. The aim of this study was to determine the percentage of Rome III IBS subjects that fulfills Rome IV criteria and to evaluate differences between Rome IV ‐positive and Rome IV‐negative subjects. Methods Four hundred and four Rome III IBS subjects completed a 14‐day end‐of‐day symptom diary, the Gastrointestinal Symptom Rating Scale ( GSRS ), Hospital Anxiety and Depression Scale, and RAND 36‐item Short‐Form Health Survey ( SF ‐36). Diary‐based surrogate Rome IV criteria were defined as occurrence of abdominal pain at least 1 day each week with a severity of ≥2 (mild; definition 1) or ≥3 (considerable; definition 2). Key Results Using surrogate Rome IV criteria, 353 (87.4%, definition 1) and 249 (61.6%, definition 2) subjects were defined as Rome IV positive. These patients were more often female, younger, and recruited from secondary/tertiary care compared with Rome IV ‐negative subjects. They also presented with higher abdominal pain scores and gastrointestinal ( GI ) symptom severity on both end‐of‐day diary and GSRS , higher psychological symptom scores, and lower quality of life compared with Rome IV ‐negative subjects. Conclusions and Inferences The Rome IV IBS population likely reflects a subgroup of Rome III IBS patients with more severe GI symptomatology, psychological comorbidities, and lower quality of life. This implies that results from Rome III IBS studies may not be directly comparable to those from Rome IV IBS populations.

Rome <scp>III</scp> vs Rome <scp>IV</scp> criteria for irritable bowel syndrome: A comparison of clinical characteristics in a large cohort study

Rome III vs Rome IV criteria for irritable bowel syndrome: A comparison of clinical characteristics in a large cohort study