Original paper

Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy

Volume: 134, Issue: 22, Pages: 1738 - 1748
Published: Nov 29, 2016
Abstract
Aberrant calcium signaling may contribute to arrhythmias and adverse remodeling in hypertrophic cardiomyopathy (HCM). Mutations in sarcomere genes may distinctly alter calcium handling pathways.We analyzed gene expression, protein levels, and functional assays for calcium regulatory pathways in human HCM surgical samples with (n=25) and without (n=10) sarcomere mutations compared with control hearts (n=8).Gene expression and protein levels for...
Paper Details
Title
Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy
Published Date
Nov 29, 2016
Volume
134
Issue
22
Pages
1738 - 1748
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