Associations of 25-hydroxyvitamin D with markers of inflammation, insulin resistance and obesity in black and white community-dwelling adults

Published on Sep 1, 2016in Journal of clinical & translational endocrinology
· DOI :10.1016/J.JCTE.2016.06.002
Jennifer L. Jackson1
Estimated H-index: 1
(UAB: University of Alabama at Birmingham),
Suzanne E. Judd66
Estimated H-index: 66
(UAB: University of Alabama at Birmingham)
+ 4 AuthorsOrlando M. Gutiérrez53
Estimated H-index: 53
(UAB: University of Alabama at Birmingham)
Abstract Aims Vitamin D is a fat-soluble vitamin classically known for its role in calcium absorption and bone health. Growing evidence indicates that vitamin D deficiency may be associated with inflammation, insulin resistance, and obesity. However, prior studies examining the association of vitamin D with metabolic risk factors had relatively low representation of individuals of black race, limiting their ability to characterize associations of vitamin D and parameters of metabolic health in black vs. white individuals. Methods We examined associations of 25-hydroxyvitamin D (25(OH)D) concentrations with markers of inflammation (interleukin [IL]-6, IL-10, high sensitivity C-reactive protein [hsCRP]), insulin sensitivity (adiponectin, resistin, HOMA-IR), and obesity (body mass index [BMI], waist circumference) in 1042 participants from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a large national cohort of black and white adults 45 years or older. Results In unadjusted analyses, lower 25(OH)D concentrations were associated with higher IL-6 and hsCRP concentrations; lower adiponectin concentrations; higher HOMA-IR; and higher BMI and waist circumference ( P  0.05 for all). After adjustment for sociodemographic, clinical, lifestyle, and laboratory variables, lower 25(OH) D concentrations remained associated with lower adiponectin concentrations, higher IL–6 concentrations, higher HOMA-IR, and higher BMI and waist circumference ( P P interaction > 0.1). Conclusions Lower 25(OH)D concentrations are associated with disturbances in metabolic health in both blacks and whites. Whether correcting vitamin D deficiency could offer a beneficial therapy for disease prevention requires further study.
📖 Papers frequently viewed together
#1Nita G. Forouhi (Medical Research Council)H-Index: 111
#2Menon Rk (QMUL: Queen Mary University of London)H-Index: 1
Last. Graham A. Hitman (QMUL: Queen Mary University of London)H-Index: 84
view all 13 authors...
Aims To investigate the effect of short‐term vitamin D supplementation on cardiometabolic outcomes among individuals with an elevated risk of diabetes.
#1Christian S Wright (Purdue University)H-Index: 5
#2Eileen Weinheimer-Haus (Purdue University)H-Index: 4
Last. Wayne W. Campbell (Purdue University)H-Index: 72
view all 5 authors...
Background: Research indicates that plasma 25-hydroxyvitamin D [25(OH)D] is associated with insulin resistance, but whether regional adiposity confounds this association is unclear. Objective: This study assessed the potential influence of adiposity and its anatomical distribution on the relation between plasma 25(OH)D and insulin resistance. Methods: A secondary analysis of data from middle-aged overweight and obese healthy adults [n = 336: 213 women and 123 men; mean ± SD (range); age: 48 ± 8 ...
Background: Epidemiologic data suggest that low serum 25-hydroxyvitamin D [25(OH)D] increases insulin resistance and the risk of type 2 diabetes. Few interventional trials have assessed the effect of vitamin D on insulin metabolism, and published results are discordant. Objective: The goal of this study was to perform a detailed assessment of the effect of ergocalciferol administration on glucose and insulin metabolism in healthy people with low total 25(OH)Dtotal. Design: This was a 12-wk, doub...
#1Anders H. Berg (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 34
#2Camille E. Powe (Harvard University)H-Index: 20
Last. Ravi Thadhani (Harvard University)H-Index: 98
view all 11 authors...
BACKGROUND: 24,25-Dihydroxyvitamin D [24,25(OH)2D] is a metabolite of 25-hydroxyvitamin D (25D). Blacks frequently have low total 25D without manifestations of vitamin D deficiency, suggesting that total serum 25D may incorrectly reflect vitamin D status in different racial groups. The ratio of serum 24,25(OH)2D to 25D [vitamin D metabolite ratio (VMR)] represents a new candidate biomarker for vitamin D status. METHODS: We measured 24,25(OH)2D3 and 25D3 by mass spectrometry in a random community...
#1Ruban Dhaliwal (Winthrop-University Hospital)H-Index: 13
#2Mageda Mikhail (Winthrop-University Hospital)H-Index: 16
Last. John F. Aloia (Winthrop-University Hospital)H-Index: 58
view all 4 authors...
Objective: The prevalence of vitamin D inadequacy is high in obese individuals. Determining the response of serum 25-hydroxyvitamin D (25[OH]D) to vitamin D3 supplementation in obese and nonobese individuals may lead to concurrent recommendations for optimal vitamin D intake in these populations. The objective of this study was to determine the dose response of vitamin D3 in subjects with a body mass index ≥35 kg/m2.Methods: Randomized, double-blind, placebo-controlled study. This study is an ex...
#1Takeki Suzuki (Johns Hopkins University)H-Index: 12
#2Jenifer H. Voeks (MUSC: Medical University of South Carolina)H-Index: 27
Last. Mary Cushman (UVM: University of Vermont)H-Index: 133
view all 9 authors...
OBJECTIVE We evaluate associations of metabolic syndrome (MetS), C-reactive protein (CRP), and a CRP-incorporated definition of MetS (CRPMetS) with risk of all-cause mortality in a biracial population. RESEARCH DESIGN AND METHODS We studied 23,998 participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, an observational study of black and white adults ≥45 years old across the U.S. Elevated CRP was defined as ≥3 mg/L and MetS by the revised Third Report of the...
#1Meg ManginH-Index: 1
#2Rebecca SinhaH-Index: 1
Last. Kelly FincherH-Index: 1
view all 3 authors...
Introduction Inflammation is believed to be a contributing factor to many chronic diseases. The influence of vitamin D deficiency on inflammation is being explored but studies have not demonstrated a causative effect.
#1Mary CushmanH-Index: 133
#2Suzanne E. JuddH-Index: 66
Last. Neil A. ZakaiH-Index: 42
view all 9 authors...
Background and Purpose—Improved identification of those at risk of stroke might improve prevention. We evaluated the association of the cardiac function biomarker N-terminal pro–B-type natriuretic peptide (NT-proBNP) with stroke risk in the 30 239 black and white participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Methods—During 5.4 years of follow-up after enrollment in 2003 to 2007, NT-proBNP was measured in baseline blood samples of 546 subjects with ...
#1John D. SorkinH-Index: 60
#2Tadas S. Vasaitis (UMES: University of Maryland Eastern Shore)H-Index: 15
Last. Andrew P. GoldbergH-Index: 52
view all 5 authors...
We identified normal vs. abnormal 25-hydroxyvitamin D [25(OH)D] concentrations by examining the relation of 25(OH)D to non-bone‐related measures (plasma glucose, insulin resistance, lipids, blood pressure, fitness, obesity, and regional adiposity) and asking whether there is a 25(OH)D concentration above and below which the relation between 25(OH)D and outcome changes. We examined the relation between 25(OH)D and outcome by race to see whether race-specific normal ranges are needed, and we exami...
#1Eamon Laird (Trinity College, Dublin)H-Index: 20
#2Helene McNulty (Ulster University)H-Index: 56
Last. J. J. Strain (Ulster University)H-Index: 38
view all 12 authors...
Context: Inadequate vitamin D status is common within elderly populations and may be implicated in the etiology of autoimmune disease and inflammation. Few studies have investigated the relationship between vitamin D status and age-related immune dysfunction in humans. Objective: The aim of this study was to investigate the association between vitamin D status and immune markers of inflammation in a large sample of older adults. Design, Setting, and Participants: An observational investigation o...
Cited By20
Long-term dialysis involves a chronic inflammatory state and produces a high prevalence of vitamin D deficiency. A clinical trial was conducted in hemodialysis with serum 25-hydroxyvitamin D (25[OH]D) level <30 ng/ml. The conventional-group (N = 35) and the high-dose group (N = 35) were treated with ergocalciferol according to the K/DOQI guidelines and double dosage of ergocalciferol from the recommendation for 8 weeks, respectively. The main outcomes were measured by serum 25[OH]D and interleuk...
Depression and vitamin D deficiency are major public health problems. The existing literature indicates the complex relationship between depression and vitamin D. The purpose of this study was to examine whether this relationship is moderated or mediated by inflammation. A community sample (n = 7162) from the LIFE-Adult-Study was investigated, for whom depressive symptoms were assessed via the German version of CES-D scale and serum 25-hydroxyvitamin D (25(OH)D) levels and inflammatory markers (...
#1Lisa M. Curtis (UAB: University of Alabama at Birmingham)H-Index: 24
#2James F. George (UAB: University of Alabama at Birmingham)H-Index: 35
Last. Anupam Agarwal (UAB: University of Alabama at Birmingham)H-Index: 71
view all 13 authors...
Acute kidney injury (AKI) remains a significant clinical problem through its diverse etiologies, the challenges of robust measurements of injury and recovery and its progression to chronic kidney d...
#1Hongyu Liu (JLU: Jilin University)H-Index: 6
#2Jiao-Qi Wang (JLU: Jilin University)H-Index: 6
Last. Zhongxin Xu (JLU: Jilin University)H-Index: 6
view all 3 authors...
Background Conflicting findings have been reported on the prognostic significance of serum 25-hydroxyvitamin D level in patients with stroke. The objective of this meta-analysis was to evaluate the prognostic utility of serum 25-hydroxyvitamin D in stroke patients.
#1Tatiana KaronovaH-Index: 8
#2Anna P. StepanovaH-Index: 2
Last. Edward B. Jude (Tameside Hospital)H-Index: 16
view all 4 authors...
We assessed the effect of different doses of vitamin D supplementation on microcirculation, signs and symptoms of peripheral neuropathy and inflammatory markers in patients with type 2 diabetes (T2DM). Sixty-seven patients with T2DM and peripheral neuropathy (34 females) were randomized into two treatment groups: Cholecalciferol 5000 IU and 40,000 IU once/week orally for 24 weeks. Severity of neuropathy (NSS, NDS scores, visual analogue scale), cutaneous microcirculation (MC) parameters and infl...
BACKGROUND Concentrations of 25-hydroxyvitamin D [25(OH)D] tend to be lower in African Americans than in non-Hispanic whites, but whether adding information on parathyroid hormone (PTH) can help explain the higher cardiometabolic risk among African Americans is unknown. OBJECTIVES This study examined race (black/white)-specific independent and joint associations of 25(OH)D and PTH with cardiometabolic biomarkers including high-sensitivity C-reactive protein (hs-CRP), estimated glomerular filtrat...
#1Angélica Scherlowski Fassula (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
Last. Yara Maria Franco Moreno (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
view all 6 authors...
OBJECTIVE To evaluate the association between MetS, its components and insulin resistance (IR) with 25(OH)D and hsCRP. The moderator role of 25(OH)D in the association of MetS, its diagnostic components and IR with hsCRP were also explored. MATERIALS AND METHODS A cross-sectional study (2014/2015) with a population-based cohort in Southern Brazil (n = 605). Metabolic syndrome (MetS) diagnosis was defined based on the Joint Interim Statement, while the Homeostasis Model Assessment of insulin resi...
#1Marta Pelczyńska (Poznan University of Medical Sciences)H-Index: 3
#2Teresa Grzelak (Poznan University of Medical Sciences)H-Index: 10
Last. Krystyna CzyżewskaH-Index: 7
view all 6 authors...
Vitamin D fractions can be involved in the pathogenesis of metabolic disorders, but their concentrations are rarely determined. The aim of this study was to evaluate the concentration of vitamin D fractions in obese hypertensive patients and to determine its associations with anthropometric parameters, glucose levels, and lipid profiles. A total of 85 obese hypertensive patients (OBHT) and 40 nonobese nonhypertensive subjects (NOBNHT) underwent biochemical measurements of lipid profiles, glycemi...
#2Aneta SitekH-Index: 11
Last. Niels Morling (UCPH: University of Copenhagen)H-Index: 68
view all 8 authors...
OBJECTIVES: Due to increasing problems with obesity and vitamin D deficiency among children, studies that tackle both problems together are needed. METHODS: Data were collected from 182 randomly selected children aged 6-13 years in primary schools in central Poland. Measures included anthropometric dimensions, body composition, questionnaires completed by participants' parents, and saliva samples. The level of 25(OH)D was assessed from the saliva samples using an enzyme-linked immunosorbent assa...
#2Wojciech SkrobotH-Index: 6
Last. Jan J. KaczorH-Index: 19
view all 9 authors...
Abstract: The aim of this experimental study was to assess whether five weeks preoperative supplementation with vitamin D will affect the intensity of pain and level of inflammatory markers in patients undergoing posterior lumbar interbody fusion (PLIF) followed by rehabilitation. 42 patients were divided by double-blind randomization into two groups: supplemented (SUPL) vitamin D (3200 IU dose of vitamin D/day for 5 weeks) and placebo group (PL) treated with vegetable oil. The 10-week program o...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.