Sepsis-induced alterations in phosphoenolpyruvate carboxykinase expression : the role of insulin and glucagon
Abstract
Sepsis is associated with a decrease in the intrinsic gluconeogenic capacity of hepatocytes. The mechanism underlying this depression is unknown. This study sought to investigate whether decreased expression of phosphoenolpyruvate carboxykinase (PEPCK), a rate limiting enzyme in hepatic gluconeogenesis, might contribute to the decreased gluconeogenesis in sepsis. Therefore, we determined the effects of sepsis on the steady-state level of PEPCK...
Paper Details
Title
Sepsis-induced alterations in phosphoenolpyruvate carboxykinase expression : the role of insulin and glucagon
Published Date
Aug 1, 1993
Journal
Volume
40
Issue
4
Pages
295 - 302
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