Downregulation and upregulation

Prostate cancer

Androgen receptor

Biology

Gene

Cancer

Androgen deprivation therapy

Cancer research

Genetics

Cancer Cell

Groner et al. show that recurrent prostate cancer-driver mutations in SPOP stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions. TRIM24 augments AR signaling; AR and TRIM24 co-activated genes are upregulated in the castration-resistant state and are predictive of disease recurrence.

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer