Biotechnology

Biology

Bone marrow

Emaciation

Immunology

In vivo

Toxicity

Internal medicine

Pharmacology

Medicine

Spleen

White blood cell

Chinese Journal of Cancer

l,6-Dimesyl-2,3- 4,5- dianhydro-L-iditol(DMDATI)was effectiveagainst w256,Yoshida subcutaneous and ascites sarcoma (YSS and YAS)of rats, S180, melanoma B16, EAC, HepA, L1210 and P388 of mice in vivo,among them W256,YSS and YAS showed higher sensitivity.DM DAI possessed cell killing effect on theL1 21 0cell. LD50 of DMDAI was 628(539-732)mg/kg forsingle ip injection and 572(456-717)mg/kg lor single ig adminstration in mice. The main toxicities were emaciation, diarrhoea and shrinkage of spleen in mice. Decrease of peripheral blood white cell and platelet Counts was observed for long-term toxicity test in dogs. Histological examination revealed depressed bone marrow, atrophy of the folliculi of spleen and hemorrhage in the intestinal mucosa. The pathologic signs could be recovered after withdrawal of the drug.

ANTITUMOR ACTIVITY AND TOXICITY OF 1,6-DIMESYL- 2 3-4. 5-DIANHYDRO-L-IDITOL IDITOL