Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.

Volume: 40, Issue: 4, Pages: 304 - 314
Published: Apr 7, 2016
Abstract
Developments in genome-wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward. However, obtaining reliable results from a Mendelian randomization investigation remains problematic, as the conventional inverse-variance weighted method only gives consistent estimates if all of the genetic variants in the analysis are valid instrumental...
Paper Details
Title
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.
Published Date
Apr 7, 2016
Volume
40
Issue
4
Pages
304 - 314
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