Animal species

Ecology

Biology

Statistics

Allometry

Extrapolation

Scaling

Mathematics

Body weight

Internal medicine

Geometry

Medicine

Zoology

Journal of Basic and Clinical Pharmacy

Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species. This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling. The method of calculation of injection volume for parenteral formulation based on human equivalent dose is also briefed.

A simple practice guide for dose conversion between animals and human