Original paper
Doxycycline administration improves fascial interface in hernia repair
Abstract
Background Despite improvements in ventral hernia repair techniques, their recurrence rates are unacceptably high. Increased levels of matrix metalloproteinases (MMPs) and reduced collagen-1 to -3 ratios are implicated in incisional hernia formation. We have recently shown doxycycline treatment for 4 wk after hernia repair reduced MMP levels, significantly increased collagen-1 to -3 ratios, and increased tensile strength of repaired interface...
Paper Details
Title
Doxycycline administration improves fascial interface in hernia repair
Published Date
Aug 1, 2014
Journal
Volume
190
Issue
2
Pages
692 - 698
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Notes
History