Internal medicine

Enzyme

Collagenase

Antibiotics

Ultimate tensile strength

Matrix metalloproteinase

Urology

Surgery

Andrology

Chemistry

Metallurgy

Materials science

Incisional hernia

Hernia repair

Doxycycline

Hernia

Fascia

Biochemistry

Medicine

Journal of Surgical Research

Despite improvements in ventral hernia repair techniques, their recurrence rates are unacceptably high. Increased levels of matrix metalloproteinases (MMPs) and reduced collagen-1 to -3 ratios are implicated in incisional hernia formation. We have recently shown doxycycline treatment for 4 wk after hernia repair reduced MMP levels, significantly increased collagen-1 to -3 ratios, and increased tensile strength of repaired interface fascia. However, this increase was not statistically significant.

Doxycycline administration improves fascial interface in hernia repair