Internal medicine

Receptor

Enzyme

Streptozotocin

Morinda

Diabetes mellitus

Endocrinology

Peroxisome

Chemistry

Troglitazone

Glutathione

Biochemistry

Traditional medicine

Medicine

Pharmacology

Asian Biomedicine

Background: Metabolic surgical procedures have been shown to improve diabetes, but the mechanism of action is poorly understood. Objective: To evaluate the antihyperglycemic and antidiabetic effects of Morinda tinctoria Roxb (MTR) fruit extract in streptozotocin (STZ)-induced diabetic rats. Methods: Albino wistar rats with STZ-induced diabetes were divided into four groups: citrate buffer, troglitazone (TGZ; 36 mg/kg), methanolic fruit extract of MTR (50 mg/kg, 100 mg/kg body weight)-administrated groups. Five, 10, and 15 days after administration of each drug, the fasting blood glucose (FBG), blood glutathione (GSH), and serum ceruloplasmin levels were measured. Results: MTR at the high dose (100 mg/kg bodyweight) produced a significant reduction in the FBG level with increase in blood GSH level. This reduction was much less than that in the FBG produced by TGZ. Treatments with TGZ or MTR at both doses did not alter the ceruloplasmin level significantly. Conclusion: MTR fruit extract contains compounds that could be effective in glucose tolerance impairment during diabetes.

Antihyperglycemic and antidiabetic effects of Morinda tinctoria Roxb using streptozotocin-induced diabetic rats