Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models
Abstract
Transcriptional dysregulation plays a major role in the pathology of Huntington's disease (HD). However, the mechanisms causing selective downregulation of genes remain unknown. Histones regulate chromatin structure and thereby control gene expression; recent studies have demonstrated a therapeutic role for histone deacetylase (HDAC) inhibitors in polyglutamine diseases. This study demonstrates that despite no change in overall acetylated...
Paper Details
Title
Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models
Published Date
Apr 4, 2007
Journal
Volume
16
Issue
11
Pages
1293 - 1306
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