Cell

Antibiotics

Viability assay

Stereochemistry

Cell culture

Biology

Cytotoxicity

Multiple drug resistance

Molecular biology

Cytotoxic T cell

Apoptosis

K562 cells

Chemistry

Efflux

In vitro

P-glycoprotein

Genetics

Biochemistry

ChemMedChem

A group of organotin(IV) complexes were prepared: [SnCy 3 (DMNI)] ( 1 ), [SnCy 3 (BZDO)] ( 2 ), [SnCy 3 (DMFU)] ( 3 ), and [SnPh 2 (BZDO) 2 ] ( 4 ), for which DMNIH=2,6‐dimethoxynicotinic acid, BZDOH=1,4‐benzodioxane‐6‐carboxylic acid, and DMFUH=2,5‐dimethyl‐3‐furoic acid. The cytotoxic activities of compounds 1 – 4 were tested against pancreatic carcinoma (PANC‐1), erythroleukemia (K562), and two glioblastoma multiform (U87 and LN‐229) human cell lines; they show very high antiproliferative activity, with IC 50 values in the 150–700 n M range after incubation for 72 h. Distribution of cellular DNA upon treatment with 1 – 4 revealed that whereas compounds 1 – 3 induce apoptosis in most of the cell lines, compound 4 does not affect cell viability in any cell line tested, indicating a possible difference in cytotoxic mechanism. Studies with the daunomycin‐resistant K562/R cell line expressing P‐glycoprotein (Pgp) showed that compounds 1 – 4 are not substrates of this protein efflux pump, indicating that these compounds do not induce acquisition of multidrug resistance, which is associated with the overexpression of Pgp.

Study of the Anticancer Properties of Tin(IV) Carboxylate Complexes on a Panel of Human Tumor Cell Lines