Fast and accurate short read alignment with Burrows–Wheeler transform

Volume: 25, Issue: 14, Pages: 1754 - 1760
Published: Jul 1, 2009
Abstract
Motivation: The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment programs. A first generation of hash table-based methods has been developed, including MAQ, which is accurate, feature rich and fast enough to align short reads from a single individual. However, MAQ does not support gapped alignment for single-end reads, which makes it unsuitable for...
Paper Details
Title
Fast and accurate short read alignment with Burrows–Wheeler transform
DOI
Published Date
Jul 1, 2009
Journal
Volume
25
Issue
14
Pages
1754 - 1760
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