Oligomer

Catalysis

Materials science

Molecule

Biosensor

Combinatorial chemistry

Nanotechnology

Organic chemistry

Chemistry

Selectivity

Bioanalysis

Force spectroscopy

Chemical Communications

We demonstrate here a novel single-molecule, label-free bioanalytical system capable of sensing the presence of specific ssDNA oligomer sequences and proteins with high selectivity and sensitivity. An ssDNA concentration of 1 nM and a Lyz concentration of 0.65 nM could be detected.

Label-free biosensing with single-molecule force spectroscopy