Genomics

Structural genomics

Sequence homology

Mathematics

Domain (mathematical analysis)

Evolutionary biology

Biology

Gene

Functional genomics

Mathematical analysis

Genome

Peptide sequence

Conserved sequence

Homology (biology)

Sequence (biology)

Protein structure

Functional analysis

Computational biology

Base sequence

Sequence alignment

Genetics

Biochemistry

Nucleic Acids Research

CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functional family (FunFams) sub-classification method and the CATH sequence domain search facility has been extended to provide FunFam annotations for each domain. The CATH website has been redesigned. We have improved the display of functional data and of conserved sequence features associated with FunFams within each CATH superfamily.

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures