Biochemistry

Isoflavonoid

Stereochemistry

Cytotoxicity

Organic chemistry

In vitro

Antioxidant

Enzyme

Prenylation

Flavonoid

Glycoside

IC50

Medicine

Chemistry

Bromide

Traditional medicine

Helvetica Chimica Acta

A new prenylated isoflavonoid, flemiphilippinin G ( 1 ), and a new flavonol glycoside, flemiphilippininside ( 2 ), along with eleven known isoflavonoids were obtained from the roots of Flemingia philippinensis ( Merr. et Rolfe) Li . Their structures were elucidated on the basis of spectroscopic data. The in vitro cytotoxicities of compounds 1 – 13 against MCF‐7, A549, and Hep‐G2 cell lines were determined by using the MTT (=3‐(4,5‐dimethylthazol‐2‐yl)‐2,5‐diphenyl‐2 H ‐tetrazolium bromide) colorimetric assay, and their antioxidant activities were evaluated by ferric‐reducing antioxidant power (FRAP) method. Compound 1 exhibited significant cytotoxicity against all the tested cell lines with IC 50 values of 4.8–7.3 μ M , and compound 2 was found to be inactive. Both compounds 1 and 2 showed weak antioxidant activities with FRAP values of 110±15 and 124±16 μmol/g, respectively.

A New Prenylated Isoflavone and a New Flavonol Glycoside from <i>Flemingia philippinensis</i>

A New Prenylated Isoflavone and a New Flavonol Glycoside from Flemingia philippinensis