Immunogenicity of protein therapeutics: The key causes, consequences and challenges
Abstract
The immunogenicity of protein therapeutics has so far proven to be difficult to predict in patients, with many biologics inducing undesirable immune responses directed towards the therapeutic resulting in reduced efficacy, anaphylaxis and occasionally life threatening autoimmunity. The most common effect of administrating an immunogenic protein therapeutic is the development of a high affinity anti-therapeutic antibody response. Furthermore, it...
Paper Details
Title
Immunogenicity of protein therapeutics: The key causes, consequences and challenges
Published Date
Oct 1, 2010
Journal
Volume
1
Issue
4
Pages
314 - 322
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