Biopsy

Biology

Lymph node

Paleontology

Vascular invasion

Vascular disease

Lymph

Stage (stratigraphy)

Internal medicine

Medicine

Disease

Cancer

Pathology

CancerVolume 27, Issue 1 p. 1-6 ArticleFree Access Further observations on the biologic significance of vascular invasion in Hodgkin's disease Stephen B. Strum MD, Stephen B. Strum MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Search for more papers by this authorGeorge B. Hutchison MD, George B. Hutchison MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Search for more papers by this authorJung K. Park MD, Jung K. Park MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Search for more papers by this authorHenry Rappaport MD, Corresponding Author Henry Rappaport MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Department of Pathology, The University of Chicago, 950 East 59 St., Chicago, Ill. 60637===Search for more papers by this author Stephen B. Strum MD, Stephen B. Strum MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Search for more papers by this authorGeorge B. Hutchison MD, George B. Hutchison MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Search for more papers by this authorJung K. Park MD, Jung K. Park MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Search for more papers by this authorHenry Rappaport MD, Corresponding Author Henry Rappaport MD Department of Pathology, The Prizker School of Medicine of the University of Chicago, and the Argonnc Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago, Ill.Department of Pathology, The University of Chicago, 950 East 59 St., Chicago, Ill. 60637===Search for more papers by this author First published: January 1971 https://doi.org/10.1002/1097-0142(197101)27:1<1::AID-CNCR2820270102>3.0.CO;2-ACitations: 17AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Vascular invasion was detected in the pretreatment lymph node biopsy sections in 9, or 5.9%, of 153 patients with Stage I or II Hodgkin's disease. This finding was associated with a greater than twofold increase in extension of disease to nonadjacent areas and with a life-table survival at 18 months almost one-half that of cases without evidence of vascular invasion. Of the 9 cases of vascular invasion, 4 occurred in Hodgkin's disease of the nodular sclerosing type and 4 in Hodgkin's disease with mixed cellularity. The finding of vascular invasion in lymph node biopsy sections from patients with Hodgkin's disease regardless of histologic type appears to be a feature indicating an increased risk of the occurrence of nonadjacent or extranodal disease, or both. Citing Literature Volume27, Issue1January 1971Pages 1-6 ReferencesRelatedInformation

Further observations on the biologic significance of vascular invasion in Hodgkin's disease