Catalysis

Materials science

Azide

Scope (computer science)

Computer science

Combinatorial chemistry

Nanotechnology

Organic chemistry

Mathematics

Cycloaddition

Alkyne

Click chemistry

Chemistry

Programming language

Química Nova

The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years.It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily accessible building blocks containing various functional groups.The great success of this reaction is based on the fact that it is general, virtually quantitative and very robuste.The scope of this copper-catalyzed synthesis is extraordinary and the reaction has found numerous applications in many research fields, including biological chemistry and materials science.In this review, the main chemical aspects and applications of the "click" reaction in the synthesis of 1,2,3-triazoles are presented.

A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações