Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction.

Volume: 85, Pages: 18 - 26
Published: Oct 1, 2014
Abstract
null null Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the release of high mobility group box-1 (HMGB1), a protein considered representative of damage-associated molecular patterns. We found that GL bound HMGB1 but not RAGE with a moderate equilibrium dissociation constant value based on surface plasmon resonance analysis. This complex formation prevented HMGB1 from binding to RAGE in vitro. The...
Paper Details
Title
Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction.
Published Date
Oct 1, 2014
Volume
85
Pages
18 - 26
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