#1Yong Il Chung(Gwangju Institute of Science and Technology)H-Index: 2
#2Jong Chul Kim(Gwangju Institute of Science and Technology)H-Index: 8
Last. Ick Chan Kwon(KIST: Korea Institute of Science and Technology)H-Index: 107
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Abstract The poly (lactide-co-glycolide) (PLGA)-based nanoparticles, coated by the heparin- or chitosan-Pluronic conjugate, were used to improve a relatively low tumor-targeting efficiency of the bare PLGA nanoparticles. The prepared nanoparticles were in the size range of 100–150 nm, and the surface exposure of the functional moiety (heparin or chitosan) was confirmed by negatively or positively increased zeta potential values, respectively. The viability tests for both normal and tumor cells d...
Surface modification of biomaterials has been adopted over the years to improve their biocompatibility. In this study, aiming to promote hydrophilicity and to introduce natural recognition sites onto poly(L-lactic acid) (PLLA) films, chitosan and its derivatives, carboxymethyl chitosan(CMC) and N-methylene phosphonic chitosan (NPC), were used to modify the surface of PLLA films by an entrapment method. Radiolabeled (125I) proteins were used to measure the amount of protein adsorbed to PLLA surfa...
#1Fan Xin(CSU: Central South University)H-Index: 2
#2Chen Jian(CSU: Central South University)H-Index: 2
Last. Zou Jian-peng(CSU: Central South University)H-Index: 7
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HA/PLGA composites with and without APS-modification were successfully prepared via solution dispersion method. The mechanical test of composites was performed by the three-point-bending test and the micrographs of materials were observed using SEM. The results indicate that by surface modification, uniform HA particles without agglomeration were obtained. Furthermore, the bending strengths and moduli of APS-HA/PLGA composites are higher than those of unmodified composites, which both first incr...
Abstract This report describes a new surface-treatment technique for cell micropatterning. Cell attachment was selectively controlled on the glass surface using a photochemical reaction. This strategy is based on combining 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, which is known to reduce non-specific adsorption, and a photolabile linker (PL) for selective cell patterning. The MPC polymer was coated directly on the glass surface using a straightforward surface modification method, ...
Abstract The objective of this study was to compare the biological effects of two key cell-adhesive proteins, fibronectin (FN) and vitronectin (VN), upon adsorption onto molecularly-designed model surfaces. Single-component and mixed self-assembled monolayers (SAMs) of alkanethiols on gold with OH and CH 3 terminal groups were prepared at 100%, 65%, 36% and 0% of OH at the surface, to generate a range of surfaces with a simple chemistry and a wettability gradient. FN and VN were adsorbed under n...
Last. Jae-Do Nam(SKKU: Sungkyunkwan University)H-Index: 57
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Abstract The hydrophobicity of the poly( l -lactide) (PLLA) surface was modified by incorporating hydroxyapatite (HAp) nanocrystalline particles during the electrospinning process for the engineered scaffold applications. The HAp nanocrystals were synthesized with 30 nm in diameter and 100–120 nm in length, which subsequently formed micrometer-sized agglomerates in the range of 2.5 μm. The synthesized HAp agglomerates were electrospun in the PLLA solution, and the HAp nanocrystals were desirably...
#1Hong Chen(WUT: Wuhan University of Technology)H-Index: 46
#2Lin Yuan(WUT: Wuhan University of Technology)H-Index: 26
Last. Dan Li(WUT: Wuhan University of Technology)H-Index: 24
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Abstract Biocompatibility is one of the most important characteristics of a biomedical polymer material whose surface is required to interact with a biological system. Such interactions between polymer surfaces and organisms have been the focus of many studies. Since proteins are viewed as the primary and the most important player in mediating polymer–organism interactions, the status of the proteins on a material surface is believed to determine the ultimate biocompatibility of a given polymer....
Last. James D. Bryers(UW: University of Washington)H-Index: 34
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Nafion™ is the membrane material preferred for in situ glucose sensors. Unfortunately, surface properties of Nafion promote random protein adsorption and eventual foreign body encapsulation thus leading to loss of glucose signal over time. Here we detail surface modifications made by RF plasma deposition to Nafion with the intent to prevent random protein adsorption while providing enough functional sites (hydroxyl groups) to bind a biologically active peptide known to induce cellular adhesion (...
Last. Changren Zhou(JNU: Jinan University)H-Index: 5
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Surface modification of biomaterials has been adopted over the years to improve their biocompatibility. In this study, aiming to promote hydrophilicity and to introduce natural recognition sites onto poly(L-lactic acid) (PLLA) films, chitosan and its derivatives, carboxymethyl chitosan (CMC) and N-methylene phosphonic chitosan (NPC), were used to modify the surface of PLLA films by an entrapment method. The surface properties of original and modified PLLA films were measured by using water conta...
Surfaces play an important role in a biological system for most biological reactions occurring at surfaces and interfaces. The development of biomaterials for tissue engineering is to create perfect surfaces which can provoke specific cellular responses and direct new tissue regeneration. The improvement in biocompatibility of biomaterials for tissue engineering by directed surface modification is an important contribution to biomaterials development. Among many biomaterials used for tissue engi...
: Tissue engineering and regenerative medicine rely extensively on biomaterial scaffolds to support cell adhesion, proliferation, and differentiation physically and chemically in vitro and in vivo. Changes to the surface characteristics of the scaffolds have the greatest impact on cell response. Here, we discuss five dominant surface modification approaches used to biomimetically improve the most common scaffolds for tissue engineering, those based on aliphatic polyesters. Scaffolds of aliphatic...
Last. Rafal J. Wiglusz(PAN: Polish Academy of Sciences)H-Index: 16
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Abstract The aim of this study was to determine the cytocompatibility of poly ( l -lactide) (PLLA) scaffolds fabricated using co-rotating twin screw extrusion technique and functionalized with different concentrations of nano-hydroxyapatite (nHAp). The efforts were aimed on the designing bioactive scaffolds improving the viability and metabolic activity of human adipose-derived multipotent stromal cells (hASCs). The in vitro study was designed to determine the optimal nHAp concentration, based o...
#2Alla B. Gilman(RAS: Russian Academy of Sciences)H-Index: 9
Last. A. N. Zelenetskii(RAS: Russian Academy of Sciences)H-Index: 12
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The literature on the modification of polylactide by high-energy chemistry methods including low-temperature plasma treatment, laser and electron-beam irradiation, bombardment with high-energy ions, and γ-irradiation has been surveyed. The main procedures for polylactide treatment by plasma, facilities used in these processes, and instrumental methods for the characterization of changes in the chemical structure and properties of the polymer have been described. Data on the application of polyla...
Last. Changren Zhou(JNU: Jinan University)H-Index: 37
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Electrospun poly(l-lactic acid) (PLLA) nanofiber mats were successfully modified by deposition of multilayers with chitosan (CS), heparin (Hep) and graphene oxide (GO) through electrostatic layer-by-layer (LBL) self-assembly method. In this study, the surface properties of PLLA nanofiber mats before and after modification were investigated via scanning electron microscope (SEM), atomic force microscopy (AFM), attenuated total reflectance fourier transformation infrared spectroscopy (ATR-FTIR), X...
Last. Changren Zhou(JNU: Jinan University)H-Index: 37
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Abstract A simple but straightforward approach was reported to prepare fiber mats modified with fibronectin (Fn) protein for endothelial cells activity study. Based on the self-polymerization and strong adhesion feature of dopamine, poly L-Lactic acid (PLLA) fibers mat was modified via simply immersing them into dopamine solution for 16 h. Subsequently, Fn was immobilized onto the fiber mats surface by the coupling reactive polydopamine (PDA) layer and Fn. Attenuated total reflectance Fourier tr...
#1Hao Ni(Northwest University (United States))H-Index: 1
#2Yan-Bing Wang(Northwest University (United States))H-Index: 5
Last. Yong-Kuan Gong(Northwest University (United States))H-Index: 19
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Control over cell–material surface interactions is the key to many new and improved biomedical devices. In this study, we present a simple yet effective surface modification method that allows for the surface reconstruction and formation of cell outer membrane mimetic structure on coatings that have significantly increased hemocompatibility. To achieve this, a phosphorylcholine end-capped poly(butylene succinate) (PBS-PC) was synthesized and dip-coated on coverslips. The surface structure of the...
The surface modification of existing polymeric biomaterials represents a key strategy for improving the hemocompatibility in long- and short-term biomedical materials without altering their bulk properties. Several techniques have been widely explored to generate surfaces that can prevent the activation of the coagulation system and lead to subsequent clot formation on the surfaces of polymeric blood contacting devices. In particular, strategies whereby the base polymer is blended with surface a...
We tested the hypothesis that the level of protein adsorption onto polyelectrolyte multilayers (PEMs) is influenced by the chain stiffness of the polymers forming the multilayer. The implication being that by altering the chain stiffness, PEMs can be formed that promote or inhibit protein adsorption. Protein adsorption to PEMs consisting of flexible and semi-flexible polyelectrolytes was investigated. The flexible polyelectrolytes were poly(sodium 4-styrene sulfonate) (PSS) and poly(diallyldimet...