Context (archaeology)

Programmed cell death

Cell biology

Biology

Cytosol

Endocrinology

Apoptosis

Neurodegeneration

Nitric oxide

Biochemistry

Poly ADP ribose polymerase

Cell injury

Paleontology

Oxidative stress

Enzyme

Polymerase

Internal medicine

Medicine

Chemistry

DNA damage

Disease

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production can cause cell death through oxidative stress, disrupted energy metabolism, DNA damage, activation of poly(ADP-ribose) polymerase, or dysregulation of cytosolic calcium. Such disturbances can lead to either apoptotic or necrotic cell death, depending on the severity and context of the damage. Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.

Nitric oxide and cell death