Alcohol

Betulinic acid

Catalysis

Benzopyrans

Isomerization

Biology

Betulin

Genetics

Combinatorial chemistry

Organic chemistry

Reagent

Chemistry

Synthetic Communications

Betulin was convert to betulinic acid using two different synthetic routes. The first approach involved an oxidation of betulin using Jones' reagent to betulonic acid and subsequent NaBH4 reduction to betulinic acid. The second approach involved steps utilizing different protecting groups on the alcohol functional groups of betulin and Jones' oxidation to circumvent the isomerization of the secondary alcohol of betulinic acid.

A Concise Semi-Synthetic Approach to Betulinic Acid from Betulin