NOD mice

Blockade

Pancreas

Biology

Endocrinology

Receptor

Cancer research

Biochemistry

Immunology

Monoclonal antibody

Antigen

In vitro

Autoimmune disease

Cytotoxic T cell

Antibody

NKG2D

Diabetes mellitus

Immunity

NKG2D is an activating receptor on CD8+ T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8+ T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8+ T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.

NKG2D Blockade Prevents Autoimmune Diabetes in NOD Mice