Pancreas

Hypergammaglobulinemia

Fibrosis

Pancreatic duct

Pancreatitis

Pancreatic disease

Immunology

Subclass

Immune system

Autoimmune pancreatitis

Inflammation

Internal medicine

Primary sclerosing cholangitis

Medicine

Gastroenterology

Disease

Antibody

IgG4-related disease

Pathology

New England Journal of Medicine

Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid treatment. Preliminary studies suggested that serum IgG4 concentrations are elevated in this disease but not in other diseases of the pancreas or biliary tract.

High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis