Quantitative volumetric analysis of progressive hemifacial atrophy corrected using stromal vascular fraction-supplemented autologous fat grafts.

Published on Oct 1, 2013in Dermatologic Surgery2.567
· DOI :10.1111/DSU.12310
Qiang Chang7
Estimated H-index: 7
(Southern Medical University),
Jie Li5
Estimated H-index: 5
(Southern Medical University)
+ 2 AuthorsFeng Lu16
Estimated H-index: 16
(Southern Medical University)
Sources
Abstract
Background Progressive hemifacial atrophy (Parry-Romberg disease) is rare and involves all skin layers and subcutaneous soft and hard tissue. Autologous fat grafting has revolutionized the field of soft-tissue reconstruction and augmentation, but long-term maintenance is unpredictable. Stromal vascular fraction (SVF)-supplemented cell therapy offers new hope for improving fat graft survival, with good long-term results, but efficacy and long-term outcome in the clinic are rarely studied using objective data. Objective To compare the long-term viability of SVF-supplemented fat grafts and fat grafts alone for contour reconstruction of progressive hemifacial atrophy using quantitative volume analysis. Methods We treated 20 patients with stable hemifacial atrophy for at least 2 years with SVF-supplemented autologous fat grafting (n = 10) or fat grafting alone (n = 10). All patients were followed up every 3 months. Hemifacial volume was measured using computed tomography and the Philips Extended Brilliance Workspace. Results All patients had successful outcomes without complications, but fat survival and clinical improvement was greater with SVF-supplemented grafting than fat grafting alone after 6 months. Conclusion SVF-supplemented autologous fat transplantation is effective and safe for treating progressive hemifacial atrophy and can enhance the survival of grafts in the face without major complications.
📖 Papers frequently viewed together
978 Citations
117 Citations
82 Citations
References0
Newest
Cited By34
Newest
#1J. Sarah Crowley (UCSD: University of California, San Diego)H-Index: 1
#2Amy Liu (UCSD: University of California, San Diego)H-Index: 6
Last. Marek Dobke (UCSD: University of California, San Diego)H-Index: 22
view all 0 authors...
This review discusses the most novel ideas and modalities being incorporated into facial rejuvenation. Recent innovative techniques include the use of regenerative stem cell techniques and regenera...
Source
#1Qianwen Lv (Peking Union Medical College)H-Index: 2
#2Xin Li (Peking Union Medical College)H-Index: 1
Last. Gui-e Ma (Peking Union Medical College)H-Index: 2
view all 6 authors...
Autologous fat grafting is common in facial reconstructive and cosmetic surgeries; the most important drawbacks are the high absorption rate and unpredictable volume retention rate. Surgeons usually make clinical judgements based on their own experience. Therefore, this study aimed to systematically and quantitatively review the volume retention rate of facial autologous fat grafting and analyse the relevant influencing factors. A systematic literature review was performed using the Medline, EMB...
2 CitationsSource
#1Aizhen Chen (Fujian Medical University)
#2Li Zhang (Fujian Medical University)
Last. Xiaosong Chen (Fujian Medical University)
view all 6 authors...
Due to the high absorption rate of traditional autologous fat grafting, cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer were developed. The purpose of this article was to evaluate the efficacy and safety of CAL and PRP in promoting the survival of autologous fat grafting through systematic review and meta-analysis. We searched Pubmed, Cochrane Library, Web of Science, and EMBASE for clinical studies on CAL and PRP-assisted lipotransfer published from January...
Source
#1Andrew Creadore (BU: Boston University)H-Index: 2
#2Jacqueline Watchmaker (BU: Boston University)H-Index: 4
Last. Neelam A. Vashi (BU: Boston University)H-Index: 11
view all 6 authors...
Unstructured Abstract Morphea and systemic sclerosis are inflammatory, sclerosing disorders. Morphea primarily affects the dermis and subcutaneous fat, while systemic sclerosis typically involves the skin and internal organs. Functional impairment and cosmetic disfigurement are common in both diseases. Treatment options to mitigate disease progression remain limited.1,2 Both functional impairment and cosmetic deficits negatively impact quality of life and psychological well-being in this patient...
Source
#1Fang-Wei LiH-Index: 1
#2Haibin WangH-Index: 3
Last. Sheng-Kang LuoH-Index: 6
view all 6 authors...
BACKGROUND: The addition of the stromal vascular fraction (SVF) can enhance the postoperative survival rate of fat. However, a universal SVF application method is currently unavailable. Therefore, a simple and convenient guideline for SVF addition is needed for its clinical application. OBJECTIVES: The authors sought to evaluate whether SVF can improve fat survival after large-volume fat grafting and to find a simple and convenient standard for the clinical use of SVF. METHODS: Patient fat sampl...
1 CitationsSource
#1Jack E BrookerH-Index: 3
#2J. Peter RubinH-Index: 60
Last. Kacey G. MarraH-Index: 64
view all 3 authors...
AbstractFat grafting was first described in the early 20th century but for many years remained a relatively underused technique due to the unreliability of long-term volume expansion. Significant improvements in reliability have been made in the last 2 decades and there is a large body of literature
4 CitationsSource
#1Jordan Gornitsky (McGill University)H-Index: 4
#1Jordan Gornitsky (McGill University)H-Index: 1
Last. Mirko S. Gilardino (Montreal Children's Hospital)H-Index: 18
view all 5 authors...
Abstract Introduction The objective of this study was to evaluate the safety and efficacy of fat grafting to the facial region for the reconstruction and aesthetic enhancement of facial contour. Methods A systematic literature review of the National Library of Medicine (PubMed), MEDLINE and Cochrane databases was performed. Studies involving the outcomes of autologous fat grafting to correct or enhance contour defects of the face were included. Extracted data included patient demographics, harve...
5 CitationsSource
#1Natalie N. ChungH-Index: 2
#2Ryan C. RansomH-Index: 15
Last. Derrick C. WanH-Index: 37
view all 10 authors...
Background:Soft tissue deficits associated with various craniofacial anomalies can be addressed by fat grafting, although outcomes remain unpredictable. Furthermore, consensus does not exist for timing of these procedures. While some advocate approaching soft tissue reconstruction after the underlyi
2 CitationsSource
#1Mingyul JoH-Index: 1
Last. Kwang-Hyun ChoiH-Index: 2
view all 8 authors...
Parry Romberg Syndrome (PRS), also known as idiopathic progressive hemifacial atrophy, is a rare neurocutaneous disorder characterized by loss of skin and subcutaneous fat of face, muscles, and bones causing unilateral atrophy. Most patients require only soft tissue augmentation although syndrome has varying grades of severity. In the majority of reported cases, it has been treated with surgical flap or autologous fat transplantation. However, these treatments need complicated surgical skills wh...
Source
#1Jin Bin KimH-Index: 2
#2Han Byeol JinH-Index: 2
Last. Jee Hyeok ChungH-Index: 2
view all 4 authors...
2 CitationsSource