CD8⁺T-cell immunosurveillance constrains lymphoid premetastatic myeloid cell accumulation

Increasing evidence suggests that premetastatic niches, consisting mainly of myeloid cells, provide microenvironment critical for cancer cell recruitment and survival to facilitate metastasis. While CD8 + T cells exert immunosurveillance in primary human tumors, whether they can exert similar effects on myeloid cells in the premetastatic environment is unknown. Here, we show that CD8 + T cells are capable of constraining premetastatic myeloid...