Annals of Clinical and Laboratory Science
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OBJECTIVE We aimed to investigate the expression of microRNA-124 (miR-124) in colon cancer and its biological function in colon cancer cells as well as its underlying mechanism. METHODS Mimic miR-124 and unrelated sequence were transfected into colon cancer HT29 cells, and a blank control group was established with untreated HT29 cells. The expression of miR-124 in each group was detected by qRT-PCR. CCK-8 assay, cell scratch assay, Transwell assay, and flow cytometry were used to detect the eff...
#1Xueqi Xie (Peking Union Medical College)H-Index: 1
Last. Peng Xie (Peking Union Medical College)H-Index: 10
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OBJECTIVE Repopulation during radiation is a classic theory in radiobiology. The long intervals between cycles of chemotherapy provide better micro-circumstance than radiation for the repopulation of cancer cells. METHODS Patients with inoperable stage III and stage IV lung cancer were enrolled prospectively. Peripheral blood and tumor tissues were obtained before treatment and each cycle of chemotherapy to detect the serum let-7a expression and Ki-67 index. RESULTS Fifty-two consecutive consent...
#1Tamar A. Smith-Norowitz (SUNY Downstate Medical Center)H-Index: 15
#2Jeffrey Loeffler (SUNY Downstate Medical Center)H-Index: 1
Last. Stephan Kohlhoff (SUNY Downstate Medical Center)H-Index: 16
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OBJECTIVE Intercellular adhesion molecule-1 (ICAM-1), an endothelial cell adhesion molecule, contributes to inflammation and immune-mediated responses. Viral infection of endothelial cells caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause vascular changes and elevate the expression of ICAM-1 in coronavirus disease 2019 (COVID-19) patients and may be used as a biomarker to measure disease severity or recovery. This study sought to identify the ICAM-1 levels in conva...
#1Zhong Li (Fujian Medical University)
#2Yimeng Zhuo (Fujian Medical University)
Last. Lijing Lin (Fujian Medical University)
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OBJECTIVE The mortality rate of non-small cell lung cancer ranks first worldwide. The lack of effective and accurate diagnosis contributes to the unfavorable prognosis of non-small cell lung cancer patients since most of them are diagnosed at an advanced stage. In the present study, we aimed to investigate whether LncRNA SNHG4 was implicated in predicting non-small cell lung cancer diagnosis and outcomes. METHODS We collected 68 unpaired serums and tissues from patients with non-small cell lung ...
#1Amadeo J. Pesce (UCSD: University of California, San Diego)H-Index: 39
#2Raymond Sundyhanata (UCSD: University of California, San Diego)
Last. Katie Bollman (UCSD: University of California, San Diego)
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OBJECTIVE The conjunction of the coronavirus disease lockdown and the use of illicit drugs suggests the potential increase in drug usage and opioid deaths. Because of other studies, we felt the need to examine if the lockdown has caused a change in the drug intake of our population of substance abuse and pain management patients. MATERIALS Urine drug testing is a strategy to reduce harm to patients in pain management and substance abuse treatment programs. We analyzed trends in the clinical drug...
#1Mamoun Younes (GW: George Washington University)
#2Andrew W. Dupont (University of Texas Health Science Center at Houston)H-Index: 13
Last. Atilla Ertan (University of Texas Health Science Center at Houston)H-Index: 24
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OBJECTIVE To elucidate the reasons for the decreased effectiveness of Vedolizumab (VDZ) treatment in patients with Crohn's disease (CD) previously treated (CD-T) with anti-TNF-α biologics. METHODS Immunohistochemical staining was performed on sections of formalin-fixed paraffin-embedded ileocolonic biopsies using antibodies for the mucosal addressin molecule (MAdCAM-1) and Etrolizumab. RESULTS The mean number of MAdCAM-1 positive capillaries (MAdCAM-1-C) was 3 in controls, 8.5 in CD, 5.37 in CD-...
#2Bingqing Li (Fourth Military Medical University)
Last. Qinhao Wang (Fourth Military Medical University)
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OBJECTIVE microRNAs may play essential roles in the development and drug resistance of non-small cell lung cancer (NSCLC). However, their functions and mechanisms are not fully understood. Our goal was to define the role of miR-145-5p in the gefitinib resistance of NSCLC. MATERIALS AND METHODS An A549 gefitinib-resistant cell line and xenograft nude mice were used in this study. The expression of miR-145-5p and its targets, NRAS and MEST, were detected and measured by qPCR, Western blot, RNA-FIS...
OBJECTIVE To investigate the role of Sirtuin 3 (SIRT3) in COVID-19 patients. METHODS This retrospective study included 97 patients with COVID-19 who were admitted to the Second People's Hospital of Xiangzhou District in Xiangyang City, Hubei Province, China from January 29, 2020 to March 15, 2020. The blood samples of the patients were obtained within 24 hours of admission. The serum levels of SIRT3 were measured by enzyme linked immunosorbent assay (ELISA). Patients received a routine whole blo...
#1Pengfei Liu (PKU: Peking University)
#2Zhongling Zhuo (PKU: Peking University)H-Index: 1
Last. Xiao-Tao Zhao (PKU: Peking University)H-Index: 1
view all 7 authors...
OBJECTIVE Breast cancer is recognized as the most common cause of malignancy and cancer death worldwide; however, mutations in the cancer-related BRCA genes are detected in only 2-3% of patients with breast cancer. Because next-generation sequencing technology allows concurrent sequencing of numerous target genes, diverse cancer-susceptibility genes are now being evaluated, although their significance in clinical practice remains unclear. METHODS In this study, we developed a sequencing panel co...
#1Feng Ye (Guangzhou Medical University)H-Index: 6
#2Peiling Zeng (Guangzhou Medical University)
Last. Shaoqiang Li (Guangzhou Medical University)H-Index: 2
view all 8 authors...
OBJECTIVE Studies have confirmed that real-time PCR detection of Aspergillus DNA in bronchoalveolar lavage fluid (BALF) is more valuable than blood samples in the diagnosis of invasive pulmonary aspergillosis (IPA). The latest guidelines recommend the use of serum samples for Aspergillus antibody testing for chronic pulmonary aspergillosis (CPA). However, research on CPA diagnosed by real-time PCR testing of BALF has been limited. In this study, we assessed the clinical value of BALF GM and PCR ...
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