Seminars in Thrombosis and Hemostasis
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#1Rebecca Pierce-Williams (Thomas Jefferson University)H-Index: 4
#2Mona M. Makhamreh (Thomas Jefferson University)H-Index: 5
Last. Huda B. Al-Kouatly (Thomas Jefferson University)H-Index: 11
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Type 1 von Willebrand disease (VWD) is the most common subtype of VWD, comprising 75% of VWD patients. We provide a systematic review of type 1 VWD in pregnancy. Our objective was to evaluate the rate of postpartum hemorrhage (PPH) in patients with known type 1 VWD. The primary outcome was rate of PPH. Primary PPH was defined as a cumulative blood loss ≥1,000 mL, or blood loss accompanied by signs and symptoms of hypovolemia within 24 hours postpartum or requiring blood products. Secondary PPH w...
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#1Youness Limami (UHSA: University of Health Sciences Antigua)H-Index: 11
#2Nezha SenhajiH-Index: 7
Last. Younes Zaid (UHSA: University of Health Sciences Antigua)H-Index: 14
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Protamine is now well recognized as a key heparin neutralizing agent. However, protamine was discovered over a century ago, during experiments performed to uncover the secrets behind heritability. Although protamine was discovered as a highly charged protein, it did not receive the attention it deserved until the dawn of insulin era, when it was used to create the neutral protamine Hagedorn formulation. Based on the same principles, protamine was identified to neutralize heparin and has since be...
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#1Massimo FranchiniH-Index: 82
#2Antonella Tufano (University of Naples Federico II)H-Index: 26
Last. Antonio CoppolaH-Index: 37
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#1Christine Lodberg Hvas (AU: Aarhus University)H-Index: 8
#2Julie Brogaard Larsen (Aarhus University Hospital)H-Index: 7
Last. Anne-Mette Hvas (Aarhus University Hospital)H-Index: 41
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Patients admitted to the intensive care unit (ICU) with coronavirus disease 2019 (COVID-19), the infectious pathology caused by severe acute respiratory syndrome coronavirus 2, have a high risk of thrombosis, though the precise mechanisms behind this remain unclarified. A systematic literature search in PubMed and EMBASE identified 18 prospective studies applying dynamic coagulation assays in ICU COVID-19 patients. Overall, these studies revealed normal or slightly reduced primary hemostasis, pr...
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#1Giuseppe Lippi (University of Verona)H-Index: 116
#2Emmanuel J. Favaloro (CSU: Charles Sturt University)H-Index: 70
Despite the huge efforts globally underway for preventing or limiting the spread of severe acute respiratory coronavirus disease 2 (SARS-CoV-2), the coronavirus disease 2019 (COVID-19) pandemic outbreak appears still virtually unstoppable. As for many other infectious diseases, COVID-19 vaccination has now become crucial for limiting viral spread, especially for averting hospitalizations, need for intensive care, and fatal outcome. Nonetheless, as for other vaccines, COVID-19 vaccination is not ...
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#1Mehran Bahraini (IUMS: Iran University of Medical Sciences)H-Index: 2
#2Akbar Dorgalaleh (IUMS: Iran University of Medical Sciences)H-Index: 17
The cardinal pathology of coronavirus disease 2019 (COVID-19) is a primary infection of pulmonary tract cells by severe acute respiratory syndrome coronavirus 2, provoking a local inflammatory response, often accompanied by cytokine storm and acute respiratory distress syndrome, especially in patients with severe disease. Systemic propagation of the disease may associate with thrombotic events, including deep vein thrombosis, pulmonary embolism, and thrombotic microangiopathy, which are importan...
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Spontaneous intracerebral hemorrhage is defined as nontraumatic bleeding into the brain without vascular malformations or presence of tumor. It occurs in about a third of all strokes and has a high mortality and morbidity. Risk factors that determine the outcome are incompletely understood. Known factors include older age, male gender, Asian ethnicity, hypertension, and comorbidity such as inherited or acquired bleeding diathesis and use of antithrombotic drugs. Likewise, the clinical characteri...
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