Toxicology Mechanisms and Methods
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#1Ritwick Bhattacharya (B. U.: University of Burdwan)H-Index: 3
#2Ismail Daoud (University of Biskra)H-Index: 4
Last. Nimai Chandra Saha (B. U.: University of Burdwan)H-Index: 13
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The purpose of this work is to evaluate the homology modeling, in silico prediction, and characterization of somatotropin and erythropoietin from Cyprinus carpio as well as molecular docking and simulation experiments between the modeled proteins and surfactants sodium dodecyl sulfate (SDS), sodium laureth sulfate (SLES) and cetylpyridinium chloride (CPC). Using the best fit template structure, homology modeling of somatotropin and erythropoietin of Cyprinus carpio respectively was conducted. Th...
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#1Ahmad Salimi (Ardabil University of Medical Sciences)H-Index: 19
#2Mohsen Niknejad (Ardabil University of Medical Sciences)
Last. Elham Mojarad Aylar (Ardabil University of Medical Sciences)
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Mitochondria have the main roles in myocardial tissue homeostasis, through providing ATP for the vital enzymes in intermediate metabolism, contractile apparatus and maintaining ion homeostasis. Mit...
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#1Rituparna Ghosh (Bhairab Ganguly College)H-Index: 1
#2Samudra Prosad Banik (Maulana Azad College)H-Index: 6
Vanadium toxicity is a globally recognised threat to the reproductive health of man and animal. However the mechanism of vanadium-induced damage to the testicular and adrenocortical tissues is not fully characterized. It was hypothesized that prostaglandins may partially mediate the inflammatory response to vanadate damage. In this study prostaglandin (PG) mediated effects of vanadate on testicular and adrenocortical functions was substantiated by using indomethacin to block prostaglandin synthe...
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#1Li Li (Shihezi University)H-Index: 1
#2Yaxin Deng (Shihezi University)H-Index: 1
Last. Guanling Song (Shihezi University)H-Index: 3
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Silica nanoparticles (SiNPs) have been widely used in nanotechnology, and more attention has been paid to their safety evaluation. However, there are still inconsistent conclusions about the genotoxicity of SiNPs. A systematic review was conducted to explore whether SiNPs have genotoxicity followed by a meta-analysis of in vivo and in vitro murine genotoxicity tests. A total of 26 eligible studies were identified in this meta-analysis through a detailed process of inclusion and exclusion, which ...
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#1Sundaram Ramalingam (University of Madras)H-Index: 2
#1Ramalingam Sundaram (University of Madras)H-Index: 10
Last. Panchanatham Sachdanandam (University of Madras)H-Index: 24
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Semecarpus anacardium Linn. (Family: Anacardiaceae), commonly known marking nuts has been used in various traditional system of medicines for various ailments (such as antiatherogenic, antiinflammatory, antimicrobial, hypoglycemic, anticarcinogenic etc) since ancient times.Based on the wide pharmacological activities of this plant, the present study was aimed to explore the antioxidant and antihyperlipidemic potential in high fat diet fed rats using catechol derivatives I-IV and biflavonoid isol...
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Doxorubicin (DOX) is the most effective and frequently used anticancer drug but its cardiotoxicity is the most important side effect that limits the clinical use of it. This work was designed to study the protective role of catechin (CAT) against DOX induced cardiotoxicity. Twenty-one adult male Wistar rats were divided into 3 groups; group (I) Control, group (II) received intraperitoneal injection of 1.66 mg/kg DOX, group (III) was pretreated with 400 mg CAT/kg orally for 2 weeks then treated w...
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#1Ertan Celik (Istanbul University)
#2Sevim Tunali (Istanbul University)H-Index: 13
Last. Refiye Yanardag (Istanbul University)H-Index: 29
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The aim of this study was to investigate the cellular mechanisms that cause valproic acid (VPA)-induced liver damage and the therapeutic effect of Vitamin U (Vit U) on these mechanisms. Female Sprague Dawley rats were randomly divided into four groups: intact control animals, animals that received Vit U (50 mg/kg/day), animals given VPA (500 mg/kg/day), and animals given both VPA and Vit U. The rats in the Vit U + VPA group were administered Vit U by gavage an hour before VPA administration ever...
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#1Hesham Farouk Hasan (Egyptian Atomic Energy Authority)H-Index: 1
#2Dalia M. Mostafa (Egyptian Atomic Energy Authority)
Last. Dina M. Lotfy (Egyptian Atomic Energy Authority)H-Index: 1
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This study investigates the concerted hepatoprotective effects for three doses of bradykinin potentiating factor (BPF) and/or followed by exposure to a low dose of γ-radiation (LDR) against Naja haje envenoming in rats. Male rats were injected with three consecutive doses of BPF (1 μg/g i.p. for 3 days), followed by exposure to a low dose of gamma radiation (0.5 Gy), and then rats were injected with a dose of Naja haje venom (250 μg/kg i.p.). Results showed that Naja haje causes liver damage, si...
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#1Feng Dong (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 1
Last. Yimin Cao
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The effect of Pulsatilla saponin A (PsA) on acute myocardial infarction (AMI) was unknown. This study targeted to examine the roles of PsA on hypoxia-triggered toxicity to H9c2 cells and reveal the potential mechanism. H9c2 cells were maintained under a hypoxic environment for 12 h to construct the AMI cell model and the cells were pretreated by PsA. Hypoxia triggered toxicity to H9c2 cells and the anti-toxicity effect of PsA was evaluated by CCK8, TUNEL, and Western blot. The levels of miR-24-3...
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#1Weiya Cao (Anhui University of Science and Technology)H-Index: 4
#2Jiafeng Gao (Anhui University of Science and Technology)
Last. Xiaolong Tang (Anhui University of Science and Technology)H-Index: 10
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Aflatoxin B1 (AFB1), a kind of mycotoxin, exerts its cytotoxicity by increasing the oxidative damage of target organs, especially the liver. In vivo and in vitro experiments were carried out to elu...
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