Toxicology Mechanisms and Methods
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#1Langying Ou (Kyoto University)
#2Akiko Honda (Kyoto University)H-Index: 20
Last. Hirohisa Takano (Kyoto University)H-Index: 64
view all 9 authors...
A diesel exhaust particle (DEP) is a type of particulate matter that is easily produced from combustion in a diesel power engine. It has been reported that DEPs can cause short- and long-term health problems. This is because DEPs are complex mixtures that are highly inhalable through the airways due to their small particle size. However, the relationship between intracellular localization of DEPs after their deposition in the lungs and the subsequent biological responses remains to be clarified....
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#1Joyce Oloaigbe Ogidigo (UNN: University of Nigeria)H-Index: 4
#2Chioma Assumpta Anosike (UNN: University of Nigeria)H-Index: 7
Last. Okwesili Fred Chiletugo Nwodo (UNN: University of Nigeria)H-Index: 7
view all 6 authors...
Toxic metals such as aluminium accumulation in the brain have been associated with the pathophysiology of several neurodegenerative disorders. Bryophyllum pinnatum leaves contain a vast array of polyphenols, particularly flavonoids, that may play a role in the prevention of toxic and degenerative effects in the brain. This study assessed the neuro-restorative potential of leaves of B. pinnatum enriched flavonoid fraction (BPFRF) in aluminium-induced neurotoxicity in rats. Neurotoxicity was induc...
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#1Chengyu LvH-Index: 2
#2Zhengyi WeiH-Index: 5
Last. Yongjun WangH-Index: 6
view all 10 authors...
Phthalate esters (PAEs) are important pollutants in the environment, which can interfere with the endocrine system by mimicking estrogen. However, limited information is available on modulating the estrogen receptor (ER) of five PAEs including di (2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), benzyl butyl phthalate (BBP), diphenyl phthalate (DPhP) and dicyclohexyl phthalate (DCHP). This study evaluated the agonistic effects of PAEs on human ER. The cytotoxicity assay showed that t...
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#1Jianan Li (Xuzhou Medical College)
#2Haoran Bi (Xuzhou Medical College)
Atrazine (ATR), a commonly applied herbicide in agriculture, has been found to cause hippocampal injury in rodents. However, the underlying toxicological targets and mechanisms are unclear. In this study, network pharmacology analysis and in vitro model were integrated to investigate the effect and mechanism of ATR induced hippocampal neurotoxicity. In total, 71 targets of hippocampal neurotoxicity induced by ATR were predicted. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes enri...
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#1Heba H. MetwalyH-Index: 1
#2Shadia A. Fathy (ASU: Ain Shams University)H-Index: 9
Last. Mona A. El-BanaH-Index: 7
view all 8 authors...
Alpha-lipoic acid (α-LA) is characterized by its unpleasant odor, poor bioavailability and stability. Nanotechnology was applied to overcome this limitation. So we aimed in this study to formulate α-LA in two different forms of chitosan nanoparticles (CsNPs) and solid lipid nanoparticles (SLNPs) and characterize them in terms of physical properties and biological activities against aluminum chloride (AlCl3)-induced neurotoxicity in rats. The vivo study was processed on 50 rats divided into 5 gro...
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#1Qian Zhang (HMU: Hebei Medical University)H-Index: 1
#2Yan Liu (HMU: Hebei Medical University)H-Index: 6
Last. Yanli Luo (HMU: Hebei Medical University)H-Index: 1
view all 7 authors...
BACKGROUNDS miR-26a-5p is a short noncoding RNA that is abnormally expressed in drug-induced liver injury (DILI), but its pathophysiologic role in the mechanism of disease in DILI is still vague. METHODS The expression of miR-26a-5p, viability of hepatic stellate cells (HSCs) proliferation, and apoptosis were explored via real-time PCR, CCK-8 assay, Tunel fluorescence, and flow cytometry. The expression of Bid was detected via Western blot assays, real-time PCR, and immunofluorescence. The apopt...
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#1Matheus Pedrino (UFSCar: Federal University of São Carlos)H-Index: 1
#2Patricia Brassolatti (UFSCar: Federal University of São Carlos)H-Index: 8
Last. Fernanda de Freitas Anibal (UFSCar: Federal University of São Carlos)H-Index: 14
view all 11 authors...
The extensive use of titanium dioxide nanoparticles (TiO2 NPs) in cosmetics, food, personal care products, and industries brought concerns about their possible harmful effects. Nowadays it has become important to assess TiO2 NPs toxic effects as a way to understand their primary risks. In the cellular environment, after cell uptake, TiO2 NPs were described to induce reactive oxygen species (ROS) production, unbalance oxidative state, and activate apoptosis in several cell lines. Therefore, we ai...
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#1Guoqing Chen (PLAGH: Chinese PLA General Hospital)
#2Faqiang Zhang (NKU: Nankai University)
Last. Zeguo Feng (PLAGH: Chinese PLA General Hospital)
view all 4 authors...
BACKGROUND The objective of this study was to investigate the role of miR-744 and its target genes in ISO protection against hypoxia/reoxygenation (H/R) induced myocardial injury. METHODS Rat cardiomyocytes H9c2 was used to establish an H/R model in vitro, and the level of miR-744 mRNA was detected by fluorescence quantitative PCR. CCK-8 and flow cytometry was used to detected cell viability and apoptosis. Myocardial injury markers CK-MB, cTnI, and LDH were detected by enzyme-linked immunosorben...
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Atopic dermatitis (AD) is characterized by progressive skin inflammation. In addition, sulforaphane is an isothiocyanate organosulfur compound from cruciferous vegetables. Sulforaphane was reported...
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#1Sofia Pina-OlmosH-Index: 1
#2Mariana Dolores-Hernández (UNAM: National Autonomous University of Mexico)H-Index: 2
view all 7 authors...
Zilpaterol and clenbuterol are two β-adrenergic agonist drugs used in animal production. Both drugs have anabolic effects with advantages on carcass yield. Meanwhile, zilpaterol is approved for animal feed in authorized countries. Clenbuterol is a banned substance due to the risk of toxicity; however, it is still being used in unknown dose levels in many farm species. Therefore, the use and abuse of these substances should be closely monitored, considering the clenbuterol ability and the not pro...
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