Toxicology Mechanisms and Methods
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#1Julio César Córdoba-Adaya (UAEM: Universidad Autónoma del Estado de México)
#2Rigoberto Oros-Pantoja (UAEM: Universidad Autónoma del Estado de México)H-Index: 5
Last. Keila Isaac-Olivé (UAEM: Universidad Autónoma del Estado de México)H-Index: 11
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The search for methods that identify early toxicity, induced by chemotherapy, is urgent. Changes in the biodistribution of radiopharmaceuticals could give information on early toxicity. Ten-week-old CD1 male mice were divided into four groups. Two groups were administered a weekly dose of 5 mg/kg of doxorubicin hydrochloride (DOX) for 5 weeks and the control groups were administered saline solution. One week after the end of treatment, the biodistribution of 18F-FDG and 67Ga-citrate were carried...
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#1Pınar Koroglu-Aydın (Haliç University)
#2Bertan Boran Bayrak (Istanbul University)H-Index: 4
Last. Refiye Yanardag (Istanbul University)H-Index: 29
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BACKGROUND Diabetes and cancer have common physiological and biochemical mechanisms. Metformin is the preferred drug of choice for the treatment of diabetes. Prostate cancer can be modeled in by injection of MAT-Lylu cells. A model of diabetes in rats is induced by streptozotocin injection. In the current study, we explored the mechanisms by which diabetes accelerates cancer, and evaluated the effects of metformin to know whether it has any impact against the damage caused by cancer and diabetic...
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#2Heba H. MansourH-Index: 2
Last. Mona M. Kamal (Al-Azhar University)H-Index: 2
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CONCLUSION Concomitant use of Anastrozole with radiation seems to attenuate radiation-induced pulmonary toxicity via TGF-β/Smad 3 and TGF-β/PDGF pathways in rats.
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#1Veronica Zingales (University of Valencia)H-Index: 4
#2Mónica Fernández-Franzón (University of Valencia)H-Index: 16
Last. María-José Ruiz (University of Valencia)H-Index: 23
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Sterigmatocystin (STE) is a common mycotoxin found in food and feed. Many studies showed that STE is genotoxic. However, up to now, the potential genotoxicity of STE on human neuronal system remains unknown. In this study, we explored the effect of STE on DNA damage and cell-cycle progression on human neuroblastoma SH-SY5Y cells exposed to various concentrations of STE (0.78, 1.56 and 3.12 µM) for 24 h. The results indicated that STE exposure induced DNA damage, as evidenced by DNA comet tails f...
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#2Yanwu Jin (SDU: Shandong University)
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Isoflurane is a commonly used inhalation anesthetic in the clinic, which can induce cognitive dysfunction and neuroinflammation. miR-212-5p has been demonstrated to be involved in the neuronal syst...
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#1Samah A Khattab (Zagazig University)
#2Wafaa F Hussien (Zagazig University)
Last. Eman Ahmed Alaa El-Din (Zagazig University)H-Index: 3
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The major sources for human exposure to Benzo [a] pyrene (B[a]P) are contaminated food, water, and inhalation of polycyclic aromatic hydrocarbon. B[a]P is a well-known human genotoxic carcinogen (I...
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#1Valentin P. Volobaev (KemSU: Kemerovo State University)H-Index: 5
#2S N Bach (KemSU: Kemerovo State University)
Last. Alexey V. Larionov (KemSU: Kemerovo State University)
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Single-cell gel electrophoresis (comet assay) is a valuable test that can be used in ecotoxicological, epidemiological, and biomonitoring contexts. We assessed the effects of short- (without cryopreservation) and long-term (with cryopreservation) storage of DMEM-cultivated human peripheral blood leukocytes (HPBLs) and a human lung fibroblast cell line (FLECH-104) on comet assay results. Samples were stored for 6 or 24 h at room temperature (23°С) or 4 °C and frozen at -80 °C or -196 °C for 1, 2,...
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#1Krissia Franco de Godoy (UFSCar: Federal University of São Carlos)H-Index: 3
#2Joice Margareth de Almeida Rodolpho (UFSCar: Federal University of São Carlos)H-Index: 3
Last. Fernanda de Freitas Anibal (UFSCar: Federal University of São Carlos)H-Index: 13
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The search for new nanomaterials has brought to the multifactorial industry several opportunities for use and applications for existing materials. Carbon nanotubes (CNT), for example, present excellent properties which allow us to assume a series of applications, however there is concern in the industrial scope about possible adverse health effects related to constant exposure for inhalation or direct skin contact. Thus, using cell models is the fastest and safest way to assess the effects of a ...
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#1Ramasamy Chandramohan (Tulane University)
#1Ramasamy Chandramohan (Tulane University)H-Index: 6
Last. Leelavinothan Pari (Annamalai University)H-Index: 67
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We investigated the antihyperlipidemic effects of tyrosol in streptozotocin (STZ)-induced diabetic rats. Rats were injected intraperitoneally with STZ (40 mg/kg), and these established experimental rats were treated with tyrosol (20 mg/kg) and glibenclamide (600µg/kg) for 45 days. The observed results revealed that tyrosol treatment significantly reduced plasma glucose, plasma, and liver total cholesterol, triglycerides, free fatty acids, phospholipids, plasma low-density lipoprotein cholesterol...
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#1Satyendra Kumar Singh (MSU: Michigan State University)
#1Satyendra K. Singh (MSU: Michigan State University)H-Index: 8
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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Highly toxic industrial chemicals that are widely accessible, and hazardous chemicals like phosgene oxime (CX) that can be easily synthesized, pose a serious threat as potential chemical weapons. In addition, their accidental release can lead to chemical emergencies and mass casualties. CX, an urticant, or nettle agent, grouped with vesicating agents, causes instant pain, injury and systemic effects, which can lead to mortality. With faster cutaneous penetration, corrosive properties, and more p...
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