Physiological Reports
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2,568
Papers 3,142
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#1Adam J. Causer (University of Portsmouth)H-Index: 3
#2Maha Mohsin Khalaf (University of Portsmouth)H-Index: 1
Last. Janis K. Shute (University of Portsmouth)H-Index: 41
view all 10 authors...
Micro- and macrovascular endothelial dysfunction in response to shear stress has been observed in cystic fibrosis (CF), and has been associated with inflammation and oxidative stress. We tested the hypothesis that the cystic fibrosis transmembrane conductance regulator (CFTR) regulates endothelial actin cytoskeleton dynamics and cellular alignment in response to flow. Human lung microvascular endothelial cells (HLMVEC) were cultured with either the CFTR inhibitor GlyH-101 (20 µM) or CFTRinh-172 ...
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#1Timothy M. Moore (UCLA: University of California, Los Angeles)H-Index: 9
#2Anthony Terrazas (UCLA: University of California, Los Angeles)
Last. Jennifer M. Lang (UCLA: University of California, Los Angeles)H-Index: 7
view all 13 authors...
The metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of some aspects of the metabolic syndrome. Furthermore, previous studies have demonstrated that an individual's gut microbiome composition has a large influence on several aspects of the metabolic syndrome. However, the mechanism(s) by which physical activity may improve metabolic health are not well under...
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#1Ashmeetha Manilall (University of the Witwatersrand)H-Index: 2
#2Lebogang Mokotedi (University of the Witwatersrand)H-Index: 4
Last. Aletta M.E. Millen (University of the Witwatersrand)H-Index: 12
view all 7 authors...
OBJECTIVE To determine the mechanisms of inflammation-induced left ventricular (LV) remodeling and effects of blocking circulating tumor necrosis factor alpha (TNF-α) in a model of systemic inflammation. METHODS Seventy Sprague-Dawley rats were divided into three groups: the control group, the collagen-induced arthritis (CIA) group, and the anti-TNF-α group. Inflammation was induced in the CIA and anti-TNF-α groups. Following the onset of arthritis, the anti-TNF-α group received the TNF-α inhibi...
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#1Tromondae Feaster (CDRH: Center for Devices and Radiological Health)H-Index: 2
#2Maura Casciola (CDRH: Center for Devices and Radiological Health)
Last. Ksenia Blinova (CDRH: Center for Devices and Radiological Health)H-Index: 15
view all 4 authors...
Cardiac contractility modulation (CCM) is an intracardiac therapy whereby nonexcitatory electrical simulations are delivered during the absolute refractory period of the cardiac cycle. We previously evaluated the effects of CCM in isolated adult rabbit ventricular cardiomyocytes and found a transient increase in calcium and contractility. In the present study, we sought to extend these results to human cardiomyocytes using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to...
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#1Liming Wang (Duke University)H-Index: 18
#2Yuping Tang (Duke University)H-Index: 3
Last. Robert F. Spurney (Duke University)H-Index: 33
view all 4 authors...
Glomerular podocytes play a key role in proteinuric diseases. Accumulating evidence suggests that cGMP signaling has podocyte protective effects. The major source of cGMP generation in podocytes is natriuretic peptides. The natriuretic peptide clearance receptor (NPRC) binds and degrades natriuretic peptides. As a result, NPRC inhibits natriuretic peptide-induced cGMP generation. To enhance cGMP generation in podocytes, we blocked natriuretic peptide clearance using the specific NPRC ligand ANP(...
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#1Arezoo Geramipour (FIU: Florida International University)H-Index: 2
#2Zachary C. Danziger (FIU: Florida International University)H-Index: 10
Age-related changes in the lower urinary tract (LUT) can affect the coordination of reflexes and increase the incidence of bladder disorders in elderly. This study examines the age-related loss of urethral signaling capability by measuring the afferent activity directly. We find that less urethral pressure develops in response to fluid flow in old rats compared to young rats and that pressure and flow evoke less urethral afferent activation. These findings are consistent with our previous study ...
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#1Matthew S. Douglass (UofU: University of Utah)H-Index: 1
#2Anna Dikalova (VUMC: Vanderbilt University Medical Center)H-Index: 19
Last. Candice D. Fike (UofU: University of Utah)H-Index: 5
view all 7 authors...
Concomitant with developing pulmonary hypertension (PH), newborn piglets exposed to chronic hypoxia develop pulmonary vascular NO signaling impairments. PH is reduced and NO signaling is improved in chronically hypoxic piglets treated with the NO-arginine precursor, L-citrulline. Folic acid positively impacts NO signaling. We evaluated whether the effect on NO signaling and PH is greater using co-treatment with folic acid and L-citrulline than either alone. From day 3 to day 10 of hypoxia, pigle...
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#2S. O. Eresko (SPbU: Saint Petersburg State University)H-Index: 2
Last. Petr D. Shabanov (Kirov Military Medical Academy)H-Index: 5
view all 5 authors...
The review presents data on the expression of growth hormone secretagogue receptor 1a (GHS-R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain. Studies show widespread distribution of the receptor in the brain, which evidences the involvement of the receptor in many physiological processes. Using various organisms, data have been obtained regarding the participation of the GHS-R1a in the regulation of the anti- and pro-inflammatory response, prolifer...
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Last. Luis C. Barrio (Polytechnic University of Puerto Rico)H-Index: 22
view all 8 authors...
Neural circuits at the brainstem involved in the central generation of the motor patterns of respiration and cardiorespiratory chemoreflexes organize as cell assemblies connected by chemical and electrical synapses. However, the role played by the electrical connectivity mainly mediated by connexin36 (Cx36), which expression reaches peak value during the postnatal period, is still unknown. To address this issue, we analyzed here the respiratory phenotype of a mouse strain devoid constitutively o...
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#1Bradley J. Petek (Harvard University)H-Index: 9
#2Timothy W. Churchill (Harvard University)H-Index: 9
Last. Meagan M. Wasfy (Harvard University)H-Index: 14
view all 9 authors...
Cardiopulmonary exercise testing (CPET) guidelines recommend analysis of the oxygen (O2 ) pulse for a late exercise plateau in evaluation for obstructive coronary artery disease (OCAD). However, whether this O2 pulse trajectory is within the range of normal has been debated, and the diagnostic performance of the O2 pulse for OCAD in physically fit individuals, in whom null null null null null V null null ˙ null null null null O null null 2 null null null null null null may be more likely to plat...
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