Therapeutic Delivery
Papers
997
Papers 1070
1 page of 107 pages (1,070 results)
Newest
Background: Nanostructured lipid carriers (NLCs) of fluconazole were prepared to improve permeability and thereby effective topical drug delivery. Materials and method: NLCs were prepared and evaluated, and then the optimized NLC suspension was incorporated into a gel that was further evaluated for topical drug delivery. Results and discussion: F-2 NLC formulation was optimized based on results of particle size (161.3 ± 1.385 nm), polydispersity index (0.401), zeta potential (-33 ± 0.46), entrap...
Source
#1Rabab Fatima (UPES: University of Petroleum and Energy Studies)H-Index: 1
#2Mousmee Sharma (Uttaranchal University)H-Index: 8
Last. Parteek Prasher (UPES: University of Petroleum and Energy Studies)H-Index: 12
view all 0 authors...
Aim: Controlled release of flufenamic acid by helical V-amylose to achieve enzyme-responsive, targeted release of the cargo drug. Materials & methods: Solid-state cross-polarization magic angle spinning carbon-13 nuclear magnetic resonance (CP/MAS NMR), Fourier transform IR and x-ray diffraction (XRD) analysis validated the entrapment of flufenamic acid inside the helical structure of V-amylose. Scanning electron microscopy (SEM) investigations established the morphology of conjugates in simulat...
Source
#1Vishal Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
#2Chintankumar V. Patel (MSU: Maharaja Sayajirao University of Baroda)H-Index: 2
Last. Hetal Thakkar (MSU: Maharaja Sayajirao University of Baroda)H-Index: 14
view all 0 authors...
Aim: The present study focused on the development of a dry emulsion tablet of raloxifene hydrochloride (RXF) using a solid carrier adsorption technique to enhance oral bioavailability. Methods: An oil-in-water emulsion was formulated and converted into dry powder using HPMC K4M plus Aerosil 200, then compressed into tablets. Results: The prepared emulsion was evaluated for globule size, drug content and zeta potential. In vitro release study revealed significantly higher release from emulsion. T...
Source
#1Yoshiki Seto (University of Shizuoka)H-Index: 15
#2Gen Suzuki (University of Shizuoka)H-Index: 5
Last. Satomi Onoue (University of Shizuoka)H-Index: 30
view all 0 authors...
Aim: Orally taken pirfenidone (PFD) often causes digestive symptoms. A respirable powder formulation of PFD (PFD-RP) was previously developed, and this study aimed to verify the risk of digestive symptoms after insufflation of PFD-RP. Materials & methods: Intestinal motility and gastrointestinal exposure levels was evaluated in PFD-RP (0.3-mg PFD/rat: a pharmacologically effective dose) and orally taken PFD (10-100 mg/kg) groups. Results & conclusion: Orally taken PFD at doses above 30 mg/kg sig...
Source
#1Anita L. Nelson (Western University of Health Sciences)H-Index: 5
A new low-dose, once-a-week contraceptive transdermal delivery system (TDS) with 2.3-mg ethinyl estradiol (EE) and 2.6-mg levonorgestrel (LNG; Twirla®) has recently been approved by the US FDA for ...
Source
#1Mitra Alami-Milani (Tabriz University of Medical Sciences)H-Index: 7
#2Sara Salatin (Tabriz University of Medical Sciences)H-Index: 13
Last. Mitra Jelvehgari (Tabriz University of Medical Sciences)H-Index: 17
view all 0 authors...
Background: Orally disintegrating tablets rapidly disintegrate in saliva and then swallowed without the need for water. Materials & methods: The orally disintegrating tablets were prepared by freeze-drying of an aqueous dispersion of isosorbide dinitrate containing a matrix former (gelatin), a cryoprotectant (mannitol), a plasticizer (glycerin) and a dissolution enhancer (Tween/polyethylene glycol). Results: Results demonstrated that the selected formulation, Ft9, disintegrated within 1 min and ...
Source
#1Elisa Lacroce (Polytechnic University of Milan)
#2Paola Saccomandi (Polytechnic University of Milan)H-Index: 27
Last. Filippo Rossi (Polytechnic University of Milan)H-Index: 26
view all 3 authors...
Source
Source
#1Mitra Alami-Milani (Tabriz University of Medical Sciences)H-Index: 7
#2Sara Salatin (Tabriz University of Medical Sciences)H-Index: 13
Last. Mitra Jelvehgari (Tabriz University of Medical Sciences)H-Index: 17
view all 4 authors...
Background: Recently, intranasal administration has been suggested as a potential direct route to transport pharmaceuticals into the brain through the olfactory and trigeminal nerves, bypassing the blood-brain barrier. Materials & methods: The nasal hydrogels were prepared by a cold method using pluronic F-12 and chitosan. Results: All the selected formulations were gelled at 30°C. The gelation time varied from 5 to 10 min. The mucoadhesive strength was adequate to provide prolonged mucosal adhe...
Source
#1Rute Pinelo (University of Lisbon)
#2Luís Roque (University of Lisbon)H-Index: 6
Last. Catarina Pinto Reis (University of Lisbon)H-Index: 24
view all 3 authors...
Diabetes is still one of the main diseases worldwide due to its high incidence, prevalence and, unfortunately, very high mortality. Type 1 diabetes (and in some other types) is generally controlled by exogenous insulin. Several attempts of oral insulin administration to humans have been done so far. Some of them achieved interesting results, but it seems to exist a barrier to transpose these studies into clinical trials. A broad perspective about the oral insulin and approaches will be addressed...
Source
12345678910
Top fields of study
Nanotechnology
Materials science
Drug delivery
Medicine
Pharmacology