Journal of Pharmacological and Toxicological Methods
IF
2.25
Papers
4102
Papers 4404
1 page of 441 pages (4,404 results)
Newest
Abstract null null Introduction null For reliable identification of cardiac safety risk, compounds should be screened for activity on cardiac ion channels in addition to hERG, including NaV1.5 and CaV1.2. We identified different parameters that might affect IC50s of compounds on NaV1.5 peak and late currents recorded using automated patch clamp (APC) and suggest outlines for best practices. null null null Methods null APC instruments SyncroPatch 384 and Patchliner were used to record NaV1.5 peak...
1 CitationsSource
#1Jongmin Ahn (University of Mississippi)H-Index: 4
#2Cristina Avonto (University of Mississippi)H-Index: 14
Last. Ikhlas A. Khan (University of Mississippi)H-Index: 71
view all 4 authors...
Abstract null null The high throughput method using dansyl cysteamine (HTS-DCYA™) is a sensitive and rapid in chemico approach to characterize skin sensitizers' thiol-reactivity. The direct quantification of fluorescent hapten-DCYA adducts facilitates the rapid testing of pure chemicals as well as mixtures. Poor solubility in acetonitrile was occasionally observed and can represent a limitation. To enable the range of solvent options compatible with the testing, the effect of binary solvent syst...
Source
#1Shoya Nagata (Nagoya University)
#2Koichi Fujiwara (Nagoya University)
Last. Harushige Ozaki (Takeda Pharmaceutical Company)H-Index: 3
view all 4 authors...
Abstract null null Drug-induced convulsion is a severe adverse event; however, no useful biomarkers for it have been discovered. We propose a new method for predicting drug-induced convulsions in monkeys based on heart rate variability (HRV) and a machine learning technique. Because autonomic nervous activities are altered around the time of a convulsion and such alterations affect HRV, they may be predicted by monitoring HRV. In the proposed method, anomalous changes in multiple HRV parameters ...
Source
#1José N. Nobrega (U of T: University of Toronto)H-Index: 50
#2Roger Raymond (CAMH: Centre for Addiction and Mental Health)H-Index: 18
Last. Bruce G. Pollock (U of T: University of Toronto)H-Index: 87
view all 4 authors...
Abstract null null A new approach is described for quantifying cholinergic receptor activation status human blood samples, based on M1 receptor-driven mobilization of intracellular calcium stores. The assay identifies anticholinergic as well as agonist cholinergic receptor activity. As a cell-based procedure, the assay shares the high efficiency of recently developed M1 receptor binding protocols, but differs from the latter in relying on fluorescence rather than radioactivity measurements. The ...
Source
Source
Source
Source
Source
Source
Source
12345678910
Top fields of study
Cardiology
Chemistry
In vivo
Safety pharmacology
Anesthesia
Medicine
Pharmacology