Neuropeptides
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#1Gokcen Guvenc-Bayram (Dokuz Eylül University)H-Index: 1
#2Murat Yalcin (Uludağ University)H-Index: 20
Abstract null null We recently demonstrated that peripheral and central administration of nesfatin-1 in fasting and satiety states generate hyperventilation activity by increasing tidal volume (TV), respiratory rate (RR), and respiratory minute ventilation (RVM). The present study aimed to investigate the mediation of central cholinergic receptors effective in respiratory control in the hyperventilation activity of nesfatin-1. Besides this, we intended to determine possible changes in blood gase...
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#1Ali Birdogan (Ege University)
#2Elif Salur (Ege University)
Last. Lutfiye KanitH-Index: 14
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Abstract null null Neuropeptide Y (NPY) and its receptors are involved in the regulation of mood, stress, and anxiety. In parallel, NPY signaling may play a vital role in the negative affective state induced by drug withdrawal. This study examined the changes in the transcript levels of NPY, Y1, Y2, and Y5 receptors in the mesocorticolimbic system during chronic nicotine exposure and withdrawal. Rats were administered with nicotine (initial dose: 25 μg/ml, maintenance dose: 50 μg/ml, free base) ...
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#1Elham Abbasloo (KMU: Kerman Medical University)H-Index: 5
#2Farzaneh Abdollahi (KMU: Kerman Medical University)
Last. Shahrbanoo Oryan (IAU: Islamic Azad University)H-Index: 24
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Abstract null null It has been shown that systemic and local administration of ultra-low dose morphine induced a hyperalgesic response via mu-opioid receptors. However, its exact mechanism(s) has not fully been clarified. It is documented that mu-opioid receptors functionally couple to T-type voltage dependent Ca+2 channels. Here, we investigated the role of T-type calcium channels, amiloride and mibefradil, on the induction of low-dose morphine hyperalgesia in male Wistar rats. The data showed ...
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#1Yan Gao (Peking Union Medical College)H-Index: 14
#2Kaichao Hu (Tianjin University of Traditional Chinese Medicine)
Last. Lan Zhang (Capital Medical University)H-Index: 13
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Abstract null null Alzheimer's disease (AD) is a serious, progressive neurodegenerative disease that involves irreversible neuronal death. Tetrahydroxy stilbene glycoside (TSG) is an active compound extracted from P. multiflorum, a traditional Chinese herbal medicine, but its role in neuroprotection is unclear. Herein, we aimed to validate the effects of TSG on APP/PS1 model mice and the underlying mechanism. RNA-seq was performed to identify differentially expressed genes in APP/PS1 mouse, with...
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#1Naoki AomatsuH-Index: 10
#2Kazuaki ShigemitsuH-Index: 2
view all 14 authors...
Abstract null null Coronavirus Disease-2019 (COVID-19), an infectious disease associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global emergency with high mortality. There are few effective treatments, and many severe patients are treated in an intensive care unit (ICU). The purpose of this study was to evaluate whether the Japanese Kampo medicine ninjin'yoeito (NYT) is effective in treating ICU patients with COVID-19. null Nine patients with confirmed SARS-CoV-2...
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Last. Mikhail Y. Sinelnikov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 4
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Abstract null null The aim of the study was to reveal the effect of neurostimulation with the TKPRPGP neuropeptide on the expression intensity of Doublecortin and Nestin in the olfactory bulb of white Wistar rats using immunohistochemical and computer analysis methods. An isolated assessment of early progenitor differentiation by the density of nestin-positive structures showed that stimulation from birth to 14 days preserves the level of nestin expression, preventing its decrease. When the admi...
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#1Mengying Chen (Xi'an Jiaotong University)
#2Xiaodong Zhang (Xi'an Jiaotong University)
Last. Shuyin Ma (Xi'an Jiaotong University)
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Abstract null null The contents of Dynorphin A(1–8) decreased gradually in ischemic cortices in rats and an intracerebroventricular administration of synthetic Dynorphin A(1–8) reduced the volume of cerebral infarction in our previous research. However, the specific protective mechanism is unclear and Dynorphin A(1–8) is unlikely to cross the blood-brain barrier (BBB) by noninvasive oral or intravenous administration as a macromolecule neuropeptide. In this study, intranasal administration was u...
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Abstract null null Disuse syndrome indicates psychosomatic hypofunction caused by excess rest and motionless and muscle atrophy is termed disuse muscle atrophy. Disuse muscle atrophy-induced muscle weakness and hypoactivity further induces muscle atrophy, leading to a vicious cycle, and this is considered a factor causing secondary sarcopenia and subsequently frailty. Since frailty finally leads to a bedridden state requiring nursing, in facing a super-aging society, intervention for a risk fact...
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#1Alireza Moein Alsadat (IUMS: Iran University of Medical Sciences)
#2Farnaz Nikbakht (IUMS: Iran University of Medical Sciences)H-Index: 12
Last. Somayeh Vazifekhah (IUMS: Iran University of Medical Sciences)
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Abstract null null Glycogen synthase kinase-3 (GSK-3) is a critical molecule in Alzheimer's disease (AD) that modulates two histopathological hallmarks of AD: Amyloid beta (Aβ) plaques and neurofibrillary tangles composed of aberrant hyper-phosphorylation of tau protein. This study was performed to investigate the protective effect of flavone apigenin through inhibition of GSK-3 and the involvement of this kinase in the inhibition of BACE1 expression and hyperphosphorylation of tau protein in an...
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#1Julia Koller (Garvan Institute of Medical Research)H-Index: 1
#2Herbert Herzog (Garvan Institute of Medical Research)H-Index: 79
Last. Lei Zhang (UNSW: University of New South Wales)H-Index: 4
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Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) are part of the extended RFamide peptide family characterized by their common arginine (R) and amidated phenylalanine (F)-motif at the carboxyl terminus. Both peptides signal through their respective high affinity G-protein coupled receptors, NPFFR2 and NPFFR1, but also show binding affinity for the other receptor due to their sequence similarity. NPFF and NPVF are highly conserved throughout evolution and can be found across the whole animal kin...
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Neuropeptide
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