Neuropeptides
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#1Jia-xiu Zhou (Southern Medical University)
#2Nian-nian Shuai (University of South China)
Last. Shao-wen Tian (GLMU: Guilin Medical University)
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Abstract Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many studies have shown that the apelin/APJ system has neuroprotective properties, such as anti-inflammatory, anti-oxidative stress, anti-apoptosis, and regulating autophagy, blocking excitatory toxicity. Apelin/APJ system has been proven to play a role in various neurological diseases and may be a promising therapeutic target for nervous system diseases. In this paper, the neuroprotective properties of t...
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#1He-Ren Gao (Anhui University of Chinese Medicine)
#2Zi-Jian Wu (Anhui University of Chinese Medicine)
Last. Mei-Qi Zhou (Anhui University of Chinese Medicine)
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Abstract Central orexinergic system contributes to the regulation of cardiovascular function. Orexinergic neurons receiving projections of nerve fibers from multiple structures of brain which involved in control and regulation of cardiovascular function locate in hypothalamus, and their axon terminals widely project to various central structures where orexins receptors are expressed. Here, we summarize the present knowledge that describes the influence of central orexinergic system on cardiovasc...
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#1Jyoti Kumbar (Karnatak University)H-Index: 1
#2C.B. Ganesh (Karnatak University)H-Index: 1
Abstract This study reports the distribution of a pro-opiomelanocortin-derived neuropeptide α–MSH in the brain of the cichlid fish Oreochromis mossambicus. α–MSH-ir fibres were found in the granule cell layer of the olfactory bulb, the medial olfactory tract, the pallium and the subpallium, whereas in the preoptic area of the telencephalon, few large MSH-ir perikarya along with extensively labeled fibres were observed close to the ventricular border. Dense network of MSH-ir fibres were seen in t...
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#1Maria Śmiałowska (PAN: Polish Academy of Sciences)H-Index: 19
#2Barbara Zięba (PAN: Polish Academy of Sciences)H-Index: 13
Last. Helena Domin (PAN: Polish Academy of Sciences)H-Index: 15
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Corticotropin releasing factor (CRF) is a neuropeptide widely distributed in the brain as a hormonal modulator and neurotransmitter. The best known behavioral function of CRF is activation of stress and anxiety via the hypothalamus and limbic structures but the role of CRF in the cortex is still poorly understood. Our previous studies have shown anxiolytic-like effects of high doses of CRF injected into the Fr2 frontal cortex and involvement of CRF1 receptors (R) in that effect. These results se...
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#1Ayse Cigel (Dokuz Eylül University)
#2Oya Sayin (Dokuz Eylül University)H-Index: 10
Last. Ataç Sönmez (Dokuz Eylül University)H-Index: 12
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Abstract Because brain development continues during adolescence, childhood trauma is a major health problem in pediatric ages. It is known traumatic brain injury (TBI) results in damage in hippocampal and cortical areas of the brain and impairs cognitive functions. The study aims to investigate the long-term effects of MK-801 (dizocilpine), an N-methyl d -aspartate (NMDA) receptor antagonist, on hippocampal damage, locomotor activity, and cognitive functions following TBI in immature rats. MK-80...
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#1Mia Levite (HUJI: Hebrew University of Jerusalem)H-Index: 5
#2Rifaat Safadi (HUJI: Hebrew University of Jerusalem)H-Index: 32
Last. Eithan Galun (HUJI: Hebrew University of Jerusalem)H-Index: 66
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Abstract T cells of aged people, and patients with cancer or severe infections (including COVID-19), are often exhausted, senescent and dysfunctional, leading to increased susceptibilities, complications and mortality. Neurotransmitters and Neuropeptides bind their receptors in T cells, and induce multiple beneficial T cell functions. Yet, T cells of different people vary in the expression levels of Neurotransmitter/Neuropeptide receptors and corresponding effects. Therefore, we performed an ind...
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#1Naoki AomatsuH-Index: 10
#2Kiyoshi MaedaH-Index: 42
Last. Kazuhiro TakeuchiH-Index: 3
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Abstract FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) plus bevacizumab is the preferred first-line treatment for right-sided metastatic colorectal cancer with RAS mutation. However, severe adverse events are common in Japanese patients. We report the successful management of multiple stage IV colorectal cancers in a patient who received multidisciplinary treatment, including chemotherapy and Japanese Kampo medicine. A 68-year-old man presented with epigastralgia and appetite...
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#1Deepthi Rapaka (Andhra University)H-Index: 4
#2Veera Raghavulu Bitra (Andhra University)H-Index: 4
Last. Annapurna Akula (Andhra University)H-Index: 10
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OBJECTIVES Alzheimer's disease is a progressive neurodegenerative disorder with cognitive and memory impairment. Benincasa hispida is being used in the treatment of various neurological diseases in Ayurveda system of medicine. The objective of the study was to investigate the effect of Benincasa hispida fruit extract in the Alzheimer's disease rats. METHODS Benincasa hispida fruits extract was administered orally for 16 weeks at doses of 250 and 500-mg/kg/day. The cognitive deficits were examine...
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#1Dávid Pintér (University of Szeged)H-Index: 3
#2Beáta Balangó (University of Szeged)H-Index: 3
Last. Zsolt Bagosi (University of Szeged)H-Index: 10
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Abstract Corticotropin-releasing factor (CRF) and the urocortins (Ucn1, Ucn2 and Ucn3) are structurally related neuropeptides which act via two distinct CRF receptors, CRF1 and CRF2, with putatively antagonistic effects in the brain. CRF and Ucn1 activate both CRF1 and CRF2, while Ucn2 and Ucn3 activate selectively CRF2. The aim of the present study was to investigate the effects of CRF, Ucn1, Ucn2 and Ucn3 on the hippocampal acetylcholine release through which they may modulate cognitive functi...
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#1Swapnil Shewale (Savitribai Phule Pune University)H-Index: 2
Last. Shobha Bhargava (Savitribai Phule Pune University)H-Index: 10
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Abstract Cocaine- and amphetamine-regulated transcript peptide (CART) is an anorexigenic neuropeptide known to play a key role in energy homeostasis across the vertebrate phyla. In the current study, we have investigated the response of the CART immunoreactive system to varying energy states in the brain of a tadpole model. The pro-metamorphic tadpoles of Euphlyctis cyanophlyctis were fasted, or intracranially injected with glucose or 2-deoxy- d -glucose (2DG; an antagonist to glucose inducing g...
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Neuropeptide
Endocrinology
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