Current Neuropharmacology
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#1Xin-zhu Yan (PRC: China Medical University (PRC))H-Index: 1
#2Laijun Lai (UConn: University of Connecticut)
Last. Yan-hui Zhang (PRC: China Medical University (PRC))H-Index: 1
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Alzheimer's disease (AD) is a progressive neurodegenerative disease which mainly affects older adults. Although the global burden of AD is increasing year by year, the causes of AD remain largely unknown. Numerous basic and clinical studies have shown that interleukin-17A (IL-17A) may play a significant role in the pathogenesis of AD. A comprehensive assessment ofthe role of IL-17A in AD would benefit the diagnosis, understanding of etiology and treatment. However, over the past decade controver...
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#1Yanbo Yang (Soochow University (Suzhou))H-Index: 6
#2Mingjia Chen (Fudan University)
Last. Zhong Wang (Soochow University (Suzhou))H-Index: 25
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BACKGROUND Erenumab is a novel monoclonal calcitonin gene-related peptide receptor antibody that is used for the preventive treatment of migraine. OBJECTIVES To evaluate overall safety and efficacy and dose-response relationship of erenumab in patients with episodic migraine and patients with prior migraine treatment failures. METHODS We searched randomized clinical trials on PUBMED, EMBASE database, and Cochrane Library database. A pair-wise meta-analysis and Bayesian network analysis were perf...
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#1Sanaz Keshavarz Shahbaz (QUMS: Qazvin University of Medical Sciences)
#2Khadijeh Koushki (QUMS: Qazvin University of Medical Sciences)
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 104
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Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic neurodegenerative disorder driven by uncontrolled extracellular deposition of β-amyloid (Aβ) in the amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. Curcumin is a hydrophobic polyphenol with noticeable neuroprotective ...
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#1Massimo Avoli (Montreal Neurological Institute and Hospital)H-Index: 78
#2Maxime Lévesque (Montreal Neurological Institute and Hospital)H-Index: 24
GABA, the key inhibitory neurotransmitter in the adult forebrain, activates pre- and postsynaptic receptors that have been categorized as GABAA, which directly open ligand-gated (or receptor-operated) ion-channels, and GABAB, which are metabotropic since they operate through second messengers. Over the last three decades, several studies have addressed the role of GABAB receptors in the pathophysiology of generalized and focal epileptic disorders. Here, we will address their involvement in focal...
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#1M V MelnikovH-Index: 6
#2A. A. SviridovaH-Index: 2
Last. Mikhail PashenkovH-Index: 16
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Dopamine is a direct mediator of neuroimmune interaction and may play a significant role in multiple sclerosis (MS) pathogenesis by modulating immune cell activity and cytokine production. We studied the effects of dopamine on Th17-cells function in 34 patients with relapsing-remitting MS and 23 healthy subjects. Production of interleukin-17 (IL-17), interferon-γ (IFN-γ), granulocyte-colony stimulating factor (GM-CSF), and IL-21 by CD4+ T-cells as well as dopamine were comparable between the gro...
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#1Ayaz Belkozhayev (KazGU: Al-Farabi University)H-Index: 1
#2Minnatallah Al-Yozbaki (CCCU: Canterbury Christ Church University)
Last. Cornelia M. Wilson (CCCU: Canterbury Christ Church University)H-Index: 15
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There are different modalities of intercellular communication governed by cellular homeostasis. In this review, we will explore one of these forms of communication called extracellular vesicles (EVs). These vesicles are released by all cells in the body and are heterogeneous in nature. The primary function of EVs is to share information through their cargo consisting of proteins, lipids and nucleic acids (mRNA, miRNA, dsDNA etc.) with other cells, which have a direct consequence on their microen...
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#1Sajad Fakhri (Kermanshah University of Medical Sciences)H-Index: 12
#2Sana Piri (Kermanshah University of Medical Sciences)H-Index: 1
Last. Haroon Khan (AWKUM: Abdul Wali Khan University Mardan)H-Index: 34
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Background null Withania somnifera (WS), also known as Ashwagandha, is commonly used in Ayurveda and other traditional medicine systems. WS has seen growing, worldwide use by the public due to its reputation as an adaptogen. This popularity has elicited increased scientific study of its biological effects, including a potential application for neuropsychiatric and neurodegenerative disorders. null Objective null This review aims to provide a comprehensive summary of preclinical and clinical stud...
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#1Yuchao Jiang (University of Electronic Science and Technology of China)H-Index: 13
#2Mingjun Duan (University of Electronic Science and Technology of China)H-Index: 14
Last. Cheng Luo (University of Electronic Science and Technology of China)H-Index: 33
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Background null Schizophrenia (SZ) is a severe psychiatric disorder typically characterized by multidimensional psychotic syndromes. Electroconvulsive therapy (ECT) is a treatment option for medication-resistant patients with SZ or to resolve acute symptoms. Although the efficacy of ECT has been demonstrated in clinical use, its therapeutic mechanisms in the brain remain elusive. null Objective null This study aimed to summarize brain changes on structural magnetic resonance imaging (sMRI) and f...
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#1Tingting Pi (Zunyi Medical College)H-Index: 1
#2Guangping Lang (Zunyi Medical College)
Last. Jingshan Shi (Zunyi Medical College)H-Index: 33
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Background null High methionine-diet (HMD) causes Alzheimer's disease (AD)-like symptoms. Previous studies have shown that Dendrobium nobile Lindle. alkaloids (DNLA) had potential benefits for AD. null Object null Whether DNLA can improve AD-like symptoms induced by HMD is to be explored. null Method null Mice were fed with 2% HMD diet for 11 weeks, the DNLA20 control group (20 mg/kg), DNLA10 group (10 mg/kg), and DNLA20 group (20 mg/kg) were administrated with DNLA for 3 months. Morris water ma...
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#1Pablo R. Silva (UFPB: Federal University of Paraíba)
#2Thallita K. S. N. Gonzaga (UFPB: Federal University of Paraíba)
Last. Bagnólia Araújo da Silva (UFPB: Federal University of Paraíba)H-Index: 13
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Autism spectrum disorder (ASD) is a neurological condition that directly affects brain functions and can culminate in delayed intellectual development, problems in verbal communication, difficulties in social interaction and stereotyped behaviors. Its etiology reveals a genetic basis which can be strongly influenced by socio-environmental factors. Ion channels controlled by ligand voltage- activated calcium, sodium, and potassium channels may play important roles in modulating sensory and cognit...
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