Diabetes-metabolism Research and Reviews
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#1Stella Papachristou (DUTH: Democritus University of Thrace)H-Index: 3
#2Djordje S. Popovic (University of Novi Sad)H-Index: 4
Last. Nikolaos Papanas (DUTH: Democritus University of Thrace)H-Index: 43
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Tirzepatide is a dual gastric inhibitory peptide/glucagon-like peptide 1 (GIP/GLP-1) receptor agonist formulated as a synthetic linear peptide, based on the native GIP sequence. It has a prolonged half-life of 5 days, which enables once-weekly dosing. Studies have hitherto demonstrated its superiority in achieving optimal glycaemic control and body weight management, as compared with various agents used in the treatment of type 2 diabetes mellitus (T2DM), including GLP-1 receptor agonists. Thus,...
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Last. Lance Alan Sloan (UTMB: University of Texas Medical Branch)H-Index: 1
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Metabolic syndrome (MS) is a chronic non-infective syndrome characterised clinically by a set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity, impaired glucose metabolism, and dyslipidaemia. These risk factors are due to a pro-inflammatory state, oxidative stress, haemodynamic dysfunction, and ischaemia, which overlap in 'dysmetabolic' patients. This review aimed to evaluate the relationship between the traditional components of MS with cardiovascular di...
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#1Junlin Qiu (Guangxi Medical University)
#2Xia Li (CSU: Central South University)H-Index: 22
Last. Zhiguang Zhou (CSU: Central South University)H-Index: 54
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Aims and objectives null Fulminant type 1 diabetes (FT1D) could present diabetes ketoacidosis (DKA) at early onset. It is crucial to identify FT1D from DKA manifestations in time at clinical practice. This study was aimed at investigating whether the fulminant index (FI), encompassing plasma glucose (PG) to glycated haemoglobin (HbA1c) ratio (PG/HbA1c), serum potassium ion (K+ ) to HbA1c ratio (K+ /HbA1c) and serum sodium ion (Na+ ) multiplied by HbA1c (Na+ *HbA1c), is a feasible indicator for e...
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#1Fabricia Dietrich (Linköping University)H-Index: 1
#2Hugo Barcenilla (Linköping University)H-Index: 4
Last. Rosaura Casas (Linköping University)H-Index: 21
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Aims null Immunomodulation with autoantigens potentially constitutes a specific and safe treatment for type 1 diabetes (T1D). Studies with GAD-alum administrated subcutaneously have shown to be safe, but its efficacy has been inconclusive. Administration of GAD-alum into the lymph nodes, aimed to optimise antigen presentation, has shown promising results in an open-label clinical trial. Herein, we compared the immune response of the individuals included in the trial with a group who received GAD...
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#1Rachele M Pojednic (Simmons College)
#2Emily Trussler (Simmons College)
Last. Elizabeth Metallinos-Katsaras (Simmons College)H-Index: 11
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Aim null To examine the association between vitamin D (25(OH)D) deficiency and risk of prediabetes in Americans 50+ years of age. null Materials and methods null This was a cross-sectional analysis of NHANES (2007-2012) subjects aged 50+ years, free of kidney/liver diseases and diabetes. Prediabetes was defined as: HbA1c level 5.7%-6.4%, or fasting plasma glucose level 100-125 mg/dL, or Oral Glucose Tolerance Test result 140-199 mg/dL, with no laboratory value in the diabetic range. The comparis...
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#1Puguang Xie (Chongqing University)
#2Bo Deng (Chongqing University)
Last. Yu Ma (Chongqing University)H-Index: 2
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Aims null The aim of this study was to evaluate the association of time in range (TIR) with amputation and all-cause mortality in hospitalised patients with diabetic foot ulcers (DFUs). null Materials and methods null A retrospective analysis was performed on 303 hospitalised patients with DFUs. During hospitalisation, TIR, mean blood glucose (MBG), coefficient of variation (CV), time above range (TAR) and time below range (TBR) of patients were determined from seven-point blood glucose profiles...
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#1Florian Gunnar Scurt (Otto-von-Guericke University Magdeburg)H-Index: 6
#2Jan MenneH-Index: 31
Last. Christos ChatzikyrkouH-Index: 10
view all 7 authors...
AIM Diabetic nephropathy (DN) is a devastating complication of diabetes mellitus (DM). Therefore, screening strategies in order to prevent its development and/or retard its progression are of paramount importance. We investigated if monocyte chemoattractant protein-1 (MCP-1) was associated with new onset microalbuminuria-the earliest sign of the albuminuric phenotype of DN- in patients with type 2 DM and normoalbuminuria. METHODS We measured MCP-1 in serum and urine samples from patients of the ...
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#1Ping Wu (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Yi Wang (HUST: Huazhong University of Science and Technology)H-Index: 3
Last. Y.H. Wen (CDC: Centers for Disease Control and Prevention)H-Index: 11
view all 16 authors...
AIMS We prospectively evaluated the association of circulating retinol-binding protein 4 (RBP4) levels in early pregnancy and risk of incident gestational diabetes mellitus (GDM) in pregnant women. METHODS A nested case-control study was conducted among 332 women who developed GDM and 664 matched controls based on the Tongji-Shuangliu Birth Cohort. GDM was diagnosed during 24-28 weeks of gestation according to the International Association of Diabetes and Pregnancy Study Group criteria. Serum RB...
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#1Sian Bradley (UNSW: University of New South Wales)H-Index: 4
#2Kevin Spring (UNSW: University of New South Wales)H-Index: 31
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The increasing prevalence of diabetes and stroke is a major global public health concern. Specifically, acute stroke patients, with pre-existing diabetes, pose a clinical challenge. It is established that diabetes is associated with a worse prognosis after acute stroke and the various biological factors that mediate poor recovery profiles in diabetic patients is unknown. The level of association and impact of diabetes, in the setting of reperfusion therapy, is yet to be determined. This article ...
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#1Giuseppe Defeudis (Università Campus Bio-Medico)H-Index: 8
#2Rossella Mazzilli (Sapienza University of Rome)H-Index: 8
Last. Daniele Gianfrilli (Sapienza University of Rome)H-Index: 24
view all 10 authors...
Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood glucose, is among the most common chronic diseases. The incidence and prevalence of DM have been increasing over the years. The complications of DM represent a serious health problem. The long-term complications include macroangiopathy, microangiopathy and neuropathy as well as sexual dysfunction (SD) in both men and women. Erectile dysfunction (ED) has been considered the most important SD in men with ...
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