Canadian Journal of Physiology and Pharmacology
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#1Yulia V. Goshovska (NASU: National Academy of Sciences of Ukraine)H-Index: 3
#2Raisa A. Fedichkina (NASU: National Academy of Sciences of Ukraine)
Last. Vadim F. Sagach (NASU: National Academy of Sciences of Ukraine)H-Index: 11
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The Frank-Starling response of the heart is known to be mediated by NO signaling, which is regulated by GSH and H2S. We hypothesized that stimulation of endogenous H2S or GSH synthesis improve Fran...
#1I. V. Rogachevskii (RAS: Russian Academy of Sciences)H-Index: 3
#2V. B. Plakhova (RAS: Russian Academy of Sciences)H-Index: 4
Last. Boris V. KrylovH-Index: 5
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A gamma-pyrone derivative, comenic acid, activates the opioid-like receptor-mediated signaling pathway that modulates the NaV1.8 channels in the primary sensory neuron membrane. These channels are ...
#1Oğuzhan Ekin Efe (Başkent University)
#2Tolga Reşat Aydos (Başkent University)H-Index: 2
Last. Selda Emre Aydingöz (Başkent University)H-Index: 1
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Acitretin is a member of vitamin A-derived retinoids and its effect on vascular smooth muscle had not been studied yet. The aim of this study is to investigate the effect of acitretin, a retinoid, ...
#1Dan Gao (Zhengzhou University)H-Index: 1
#2Pei Yu (Zhengzhou University)
Last. Ge Wu (Zhengzhou University)H-Index: 1
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Diabetic nephropathy (DN) is the most common complication of diabetic patients, and has become a global healthcare problem. In this study, we used diabetic mice to evaluate the effect of Losartan on diabetic nephropathy, in which the experimental animals were divided into three groups: non-diabetic mice (db/m group), untreated-diabetic mice (db/db group), and Losartan-treated diabetic mice (db/db-losartan). Next, immunohistochemistry and immunofluorescence were used to detect WT-1 and synaptopod...
#1Azza S. Awad (Ahram Canadian University)H-Index: 6
#2Hemat A. Elariny (Al-Azhar University)H-Index: 2
Last. Amany Said Sallam (Menoufia University)
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Background: Ischemia/reperfusion injury (IRI) is typically associated with a vigorous inflammatory and oxidative stress response to hypoxia and reperfusion that disturbs the function of the organ. ...
#1Lucas E. L. Terceiro (UM: University of Manitoba)
#2Anne Blanchard (UM: University of Manitoba)H-Index: 13
Last. Yvonne Myal (UM: University of Manitoba)H-Index: 24
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Prolactin-inducible protein (PIP) is a multifunctional glycoprotein that is highly expressed and found in the secretions of apocrine glands, such as salivary, lacrimal, and sweat glands including t...
#1Renata Fritzsche Rodrigues (UFSM: Universidade Federal de Santa Maria)H-Index: 2
#2Carolina Cristovão Martins (UFSM: Universidade Federal de Santa Maria)H-Index: 1
Last. Cristina W. Nogueira (UFSM: Universidade Federal de Santa Maria)H-Index: 68
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Studies reveal that oxidative stress is associated with morphine long-term treatment adverse effects. CF3-substituted diselenide (CF3) is a multitarget organoselenium compound that has antioxidant properties in different experimental models. This study aimed to investigate the CF3 effects against redox imbalance in peripheral and central tissues of mice, after single or multiple morphine doses. Swiss male mice received a single dose of morphine (5 mg/kg, s.c) and CF3 (10 mg/kg, i.g), or morphine...
#1Iván Rodríguez-Núñez (UdeC: University of Concepción)H-Index: 1
#2Roberto B. Pontes (UNIFESP: Federal University of São Paulo)H-Index: 6
Last. Ruy R. Campos (UNIFESP: Federal University of São Paulo)H-Index: 32
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Background. Chronic nicotine exposure may increase cardiovascular risk by impairing the autonomic function. Besides, physical exercise (PE) has shown to improve cardiovascular health. We thus aimed...
#1Jonatas E. Nogueira (USP: University of São Paulo)H-Index: 4
#2Mateus R. Amorim (USP: University of São Paulo)H-Index: 8
Last. Luiz G.S. Branco (USP: University of São Paulo)H-Index: 36
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Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its action on the deleterious effects of acute exhaustive exercise in muscle damage remain unknown. Therefo...
#1Maiara Voltarelli Providello (USP: University of São Paulo)H-Index: 2
#2Gisele Bulhões Portapilla (USP: University of São Paulo)H-Index: 5
Last. Sérgio de Albuquerque (USP: University of São Paulo)H-Index: 34
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Cardiac damage during the acute phase of Chagas disease (CD) is associated with an increase in pro-inflammatory markers and oxidative stress. Melatonin has emerged as a promising therapy for CD due to its antioxidant and immunomodulatory properties. However, the protective action of melatonin in the cardiac tissue as well as its direct action on the parasite cycle is not fully understood. We investigated the effects of melatonin on heart parasitism in mice infected with Trypanosoma cruzi (T. cru...
Top fields of study
Diabetes mellitus