Molecular and Cellular Biology
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#1Sanchita Rauth (UNMC: University of Nebraska Medical Center)H-Index: 5
#2Saswati Karmakar (UNMC: University of Nebraska Medical Center)H-Index: 7
Last. Samikshan Dutta (UNMC: University of Nebraska Medical Center)H-Index: 12
view all 14 authors...
RNA polymerase II-associated factor 1 (PAF1)/pancreatic differentiation 2 (PD2) is a core subunit of the human PAF1 complex (PAF1C) that regulates the RNA polymerase II function during transcriptional elongation. PAF1/PD2 has also been linked to the oncogenesis of pancreatic ductal adenocarcinoma (PDAC). Here, we report that PAF1/PD2 undergoes post-translational modification (PTM) through SUMOylation, enhancing the radiation resistance of PDAC cells. We identified that PAF1/PD2 is preferentially...
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#1Salar Ahmad (Laval University)H-Index: 3
#2Valérie Côté (Laval University)H-Index: 5
Last. Jacques Côté (Laval University)H-Index: 69
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The repair of DNA double-strand breaks (DSBs) occurs in chromatin and several histone post-translational modifications have been implicated in the process. Modifications of histone H2A N-terminal tail has also been linked to DNA damage response, through acetylation or ubiquitination of lysine residues that regulate repair pathway choice. Here, we characterize a new DNA damage-induced phosphorylation on chromatin, at serine 15 of H2A in yeast. We show that this SQ motif functions independently of...
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#1Yihong Huang (Ha Tai: Xiamen University)
#2Shuo Zheng (Ha Tai: Xiamen University)
Last. Liming Ke (Ha Tai: Xiamen University)
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Triple-negative breast cancer (TNBC) is an aggressive histological subtype of breast cancer. It has been reported that the circular RNA (circRNA) circ-ERBB2 (circBase identifier hsa_circ_0007766) is mainly distributed in the cytoplasm of TNBC cells and promotes the proliferation and invasion of TNBC cells. This study aimed to explore the molecular mechanism of circ-ERBB2 regulating the progression of TNBC. The expression of circ-ERBB2 was detected by quantitative real-time PCR (qRT-PCR). Loss-of...
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#1Rui Liu (St. Vincent's Institute of Medical Research)H-Index: 13
#2Ashleigh King (St. Vincent's Institute of Medical Research)H-Index: 4
Last. Jörg Heierhorst (St. Vincent's Institute of Medical Research)H-Index: 29
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Toll-like receptors (TLRs) and IL-1 receptors regulate immune and inflammatory responses by activating the nuclear factor (NF)-κB pathway. Here we report that B cell-specific loss of Dynein light chain-1 (DYNLL1, LC8) or its designated transcription factor ASCIZ (ATMIN) leads to severely reduced in vivo antibody responses to TLR4-dependent but not T cell-dependent antigens in mice. This defect was independent of DYNLL1's established roles in modulating BIM-dependent apoptosis and 53BP1-dependent...
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#1Elizabeth L. Castle (Dal: Dalhousie University)H-Index: 1
#2Carolyn-Ann Robinson (U of C: University of Calgary)H-Index: 2
Last. Jennifer A. Corcoran (U of C: University of Calgary)H-Index: 15
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Processing bodies (PBs) are ribonucleoprotein granules important for cytokine mRNA decay that are targeted for disassembly by many viruses. Kaposi's sarcoma-associated herpesvirus is the etiological agent of the inflammatory endothelial cancer, Kaposi's sarcoma, and a PB-regulating virus. The virus encodes kaposin B (KapB), which induces actin stress fibers (SFs) and cell spindling as well as PB disassembly. We now show that KapB-mediated PB disassembly requires actin rearrangements, RhoA effect...
1 CitationsSource
#1Deborah P. Lavin ('QUB': Queen's University Belfast)H-Index: 3
Last. Vijay K. Tiwari ('QUB': Queen's University Belfast)H-Index: 25
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The multistep process of epithelial-to-mesenchymal transition (EMT), whereby static epithelial cells become migratory mesenchymal cells, plays a critical role during various developmental contexts, wound healing, and pathological conditions such as cancer metastasis. Despite the established function of basic helix-loop-helix (bHLH) transcription factors (TFs) in cell fate determination, only a few have been examined for their role in EMT. Here, using transcriptome analysis of distinct stages dur...
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#1Himangshu S. Bose (Mercer University)H-Index: 23
#2Randy M. WhittalH-Index: 33
Last. Neal M Hall (Mercer University)
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Estradiol is essential for the development of female sex characteristics and fertility. Postmenopausal women and breast cancer patients have high levels of estradiol. Aromatase catalyzes estradiol synthesis; however, the factors regulating aromatase activity are unknown. We identified a new 22-kDa protein, aromatase interacting partner in breast (AIPB), from the endoplasmic reticulum of human breast tissue. AIPB expression is reduced in tumorigenic breast and further reduced in triple-negative t...
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#1Azlann Arnett (BRI: Benaroya Research Institute)
#2Keagan G Moo (BRI: Benaroya Research Institute)
Last. Vivian H. Gersuk (BRI: Benaroya Research Institute)H-Index: 22
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Immune health requires innate and adaptive immune cells to engage precisely balanced pro- and anti-inflammatory forces. We employ the concept of chemical immunophenotypes to classify small molecules functionally or mechanistically according to their patterns of effects on primary innate and adaptive immune cells. The high-specificity, low-toxicity cyclin dependent kinase 8 (CDK8) inhibitor DCA exerts a distinct tolerogenic profile in both innate and adaptive immune cells. DCA promotes Treg and T...
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#1Pruthvi Gowda (National Brain Research Centre)H-Index: 3
#2Kirti Lathoria (National Brain Research Centre)
Last. Ellora Sen (National Brain Research Centre)H-Index: 24
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De-synchronized circadian rhythm in tumors is coincident with aberrant inflammation and dysregulated metabolism. As their inter-relationship in cancer etiology is largely unknown, we investigated the link between the three in glioma. Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1β was concomitant with elevated levels of core circadian regulators Clock and Bmal1. siRNA mediated knockdown of Bmal1 and Clock decreased (i) LDHA and IL-1β levels and (ii) release of lact...
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#1Liza J. Burton (Clark Atlanta University)H-Index: 7
#2Jodi Dougan (Clark Atlanta University)H-Index: 3
Last. Valerie Odero-Marah (Clark Atlanta University)H-Index: 22
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