Nanomedicine: Nanotechnology, Biology and Medicine
Papers 6,047
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#1Alessandro Grattoni (Houston Methodist)H-Index: 25
#2John P. Cooke (Houston Methodist)H-Index: 119
#1Agnieszka Kamińska (Jagiellonian University)H-Index: 20
#2Maciej Roman (PAN: Polish Academy of Sciences)H-Index: 7
Last. Ewa Stępień (Jagiellonian University)H-Index: 29
view all 7 authors...
Abstract null null In this study, we verified the hypothesis that Raman signature of urinary extracellular vesicles (UEVs) can be used to stratify patients with diabetes at various stages of chronic kidney disease (CKD). Patients with type 2 diabetes diagnosed with different stages of CKD and healthy subjects were enrolled in the study. UEVs were isolated using low-vacuum filtration followed by ultracentrifugation. Correlation analysis, multiple linear regression and principal component analysis...
#1Paula Garcia-Belda (UV: University of Valencia)H-Index: 4
#2Helena Prima-Garcia (UV: University of Valencia)H-Index: 15
Last. Sara Gil-Perotin (San Antonio River Authority)H-Index: 17
view all 10 authors...
Abstract null null Mesenchymal stem cell therapy after stroke is a promising option investigated in animal models and clinical trials. The intravenous route is commonly used in clinical settings guaranteeing an adequate safety profile although low yields of engraftment. In this report, rats subjected to ischemic stroke were injected with adipose-derived stem cells (ADSCs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs) applying an external magnetic field in the skull to retain t...
#1Daniela Araújo (University of Minho)H-Index: 3
#2Dalila Mil-Homens (Instituto Superior Técnico)H-Index: 12
Last. Sónia Carina Silva (University of Minho)H-Index: 36
view all 7 authors...
This study was supported by the Portuguese Foundation forScience and Technology (FCT) under the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European RegionalDevelopment Fund under the scope of Norte2020-ProgramaOperacional Regional do Norte and Daniela Eira Araujo [SFRH/BD/121417/2016] PhD grant. The authors also acknowledge theproject funding by the“02/SAICT/2017–Projetos de Investiga-cao Cientifica e Desenvolvimento Tecnologico...
#1Anna Zykova (RAS: Russian Academy of Sciences)H-Index: 4
#2Elena A. Blokhina (RAS: Russian Academy of Sciences)H-Index: 6
Last. Nikolai V. Ravin (RAS: Russian Academy of Sciences)H-Index: 32
view all 7 authors...
Abstract null null The extracellular domain of the M2 protein (M2e) and conserved region of the second subunit of the hemagglutinin (HA2) could be used for the development of broad-spectrum vaccines against influenza A. Here we obtained and characterized recombinant mosaic proteins containing tandem copies of M2e and HA2 fused to an artificial self-assembling peptide (SAP). The inclusion of SAP peptides in the fusion proteins enabled their self-assembly in vitro into spherical particles with a s...
#1Chen Ma (Lanzhou University)H-Index: 5
#2Yida Zhang (CAS: Chinese Academy of Sciences)
Last. Haixia Zhang (Lanzhou University)H-Index: 34
view all 7 authors...
Abstract null null Transport ions into cells through nanocarrier to achieve ion-interference therapy provides new inspiration for cancer treatment. In this work, a pH-targeted and NIR-responsive NaCl-nanocarrier is prepared using surfactant Vitamin E-O(EG2-Glu) and modified with polydopamine (PDA) and pH-sensitive zwitterionic chitosan (ZWC). The NaCl-nanocarrier is decorated with NH4HCO3 and IR-780 to introduce near-infrared (NIR)-responsive performance and imaging. Once the NaCl-nanocarrier is...
#1Mahmoud H Teaima (Cairo University)H-Index: 5
#2Noha M. Badawi (BUE: British University in Egypt)H-Index: 2
Last. Shaker A. Mousa (ACPHS: Albany College of Pharmacy and Health Sciences)H-Index: 66
view all 6 authors...
Abstract null null The purpose of this work was to incorporate an optimized pomegranate extract loaded solid lipid nanoparticles (PE-SLNs) formula in a transdermal emulgel to evaluate its anticancer effect. The prepared emulgel formulae were evaluated for their physicochemical properties. An ex vivo permeation study was done through mouse skin and the kinetic parameters were determined. Kinetic data showed that the ex vivo permeation of PE from SLNs transdermal emulgel through mouse skin followe...
#1Andrea Cortes (The University of Texas MD Anderson Cancer Center)H-Index: 10
#2Hideyuki Nishiofuku (Nara Medical University)
Last. Rony Avritscher (The University of Texas MD Anderson Cancer Center)H-Index: 14
view all 9 authors...
Abstract null null Embolic agents used in transarterial embolization for intermediate stage hepatocellular carcinoma reduce blood flow into tumors and can deliver anticancer drugs. Tumor blood supply can be interrupted using doxorubicin-eluting beads (DEB-TACE) or non-loaded beads (TAE) of different calibers. In this preclinical study, we characterized the extent of remaining stressed tumor cells after treatment, hypoxia within the surviving tumor regions, and inflammatory immune cell infiltrate...
#1Pingyun Ge (XMU: Xiamen University)H-Index: 1
#2Yuqing Liu (XMU: Xiamen University)
Last. Xuan Zhu (XMU: Xiamen University)H-Index: 13
view all 10 authors...
Abstract null null Various drug delivery strategies to improve cancer therapeutic efficacy have been actively investigated. One major challenge is to improve the targeting ability. Here elaborately designed nanocarriers (NCs) named as Tf-5-ALA-PTX-NCs are demonstrated to address this problem. In this nanostructure, paclitaxel (PTX) and 5-aminolevulinic acid (5-ALA) were co-encapsulated within magnetic nanocarriers to achieve synergistic chemotherapy and photodynamic therapy, while transferrin (T...
#1Oihane Mitxelena-Iribarren (University of Navarra)H-Index: 4
#2C. Olaizola (University of Navarra)
Last. M. Mujika (University of Navarra)H-Index: 9
view all 4 authors...
Abstract null null Mimicking the diffusion that drugs suffer through different body tissues before reaching their target is a challenge. In this work, a versatile membrane-based microfluidic platform was developed to allow for the identification of drugs that would keep their cytotoxic properties after diffusing through such a barrier. As an application case, this paper reports on a microfluidic device capable of mimicking the diffusion that free or encapsulated anticancer drugs would suffer in ...
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