Molecular Oncology
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#1Ryo Tanabe (UTokyo: University of Tokyo)H-Index: 2
#2Kohei Miyazono (UTokyo: University of Tokyo)H-Index: 150
Last. Masato Morikawa (UTokyo: University of Tokyo)H-Index: 15
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Glioma-initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming non-adherent spheres under serum-free conditions. Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β family, induce differentiation of GICs and suppress their tumorigenicity. However, the mechanisms underlying the BMP-induced loss of GIC stemness have not been fully elucidated. Here, we show that...
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#1Dan Lin (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)H-Index: 2
#2Haiyang Zhang (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)H-Index: 23
Last. Jingjing Duan (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)H-Index: 8
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Fatty acid oxidation (FAO) plays a vital role in drug resistance in cancer cells. Carnitine palmitoyltransferase 1A (CPT1A), a key enzyme of FAO, is widely recognized as an emerging therapeutic target. Here, we confirmed that CPT1A was heterogeneously expressed in colon cancer cells, with a high expression in oxaliplatin-resistant cells but low expression in oxaliplatin-sensitive cells, and expression could be increased by oxaliplatin stimulation. In addition, we verified that CPT1A was more hig...
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#1Jinkwon Lee (Korea Research Institute of Bioscience and Biotechnology)
#2Kwangho Kim (Korea Research Institute of Bioscience and Biotechnology)H-Index: 5
Last. Ryuji HamamotoH-Index: 38
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Dozens of histone methyltransferases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human diseases such as cancer remain largely unclear. Here, we demonstrate the involvement of EHMT1, a histone lysine methyltransferase, in lung cancer. Immunohistochemical analysis indicated that the expression levels of EHMT1 are significantly elevated in human lung carcinomas compared with non-neoplastic lung tissues. Through gene ontology analysis of R...
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#1Yvonne Xinyi Lim (NUS: National University of Singapore)
#2Hexian Lin (NUS: National University of Singapore)
Last. Yoon Pin Lim (NUS: National University of Singapore)H-Index: 30
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WW-domain binding protein 2 (WBP2) is an oncogene that drives breast carcinogenesis through regulating Wnt, estrogen receptor (ER) and Hippo signaling. Recent studies have identified neoteric modes of action of WBP2 other than its widely recognized function as a transcriptional co-activator. Here, we identified a previously unexplored role of WBP2 in inflammatory signaling in breast cancer via an integrated proteogenomic analysis of The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) d...
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#1Soon Sun Kim (Ajou University)H-Index: 20
#2Geum Ok Baek (Ajou University)H-Index: 4
Last. Jung Woo Eun (Ajou University)H-Index: 5
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This study investigated the diagnostic potential of serum small extracellular vesicle-derived long noncoding RNAs (EV-lncRNAs) for hepatocellular carcinoma (HCC). Driver oncogenic lncRNA candidates were selected by a comparative analysis of lncRNA expression profiles from two whole transcriptome human HCC datasets (Catholic_LIHC and TCGA_LIHC). Expression of selected lncRNAs in serum and small EVs was evaluated using quantitative reverse transcription PCR. Diagnostic power of serum EV-lncRNAs fo...
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#1Mikkel G. Terp (University of Southern Denmark)H-Index: 12
#2Odd L. Gammelgaard (University of Southern Denmark)H-Index: 1
Last. Henrik J. Ditzel (University of Southern Denmark)H-Index: 50
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RAS-MAPK signaling promotes immune evasion and cancer cell survival, and MAPK inhibitors (MAPKi) are frequently used as cancer therapies. Despite progress elucidating the direct effects of MAPKi on immune cells, their indirect effect on the tumor microenvironment (TME) through changes in tumor cells remains incompletely understood. Here, we present evidence of a rapid compensatory response to MAPKi that is driven by sustained p38-MAPK signaling and by which cancer cells can upregulate the immuno...
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#1Richard L. Schilsky (U of C: University of Chicago)H-Index: 87
Oncologists have recognized for many years that cancer is not a single disease, but it has only been recently that the enormous biological diversity of cancer has been revealed through sophisticated molecular profiling studies of human tumors, particularly through genomic profiling. It is probable that no two cancers are alike in their genomic, transcriptomic and proteomic profiles or microenvironment. This biological heterogeneity gives rise to cancers that vary in clinical presentation, natura...
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#1Inga H. Rye (Oslo University Hospital)H-Index: 10
#2Kanutte Huse (University of Oslo)H-Index: 11
Last. Ole Christian Lingjærde (University of Oslo)H-Index: 36
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Sentinel lymph nodes are the first nodes draining the lymph from a breast, and could reveal early changes in the host immune system upon dissemination of breast cancer cells. To investigate this, we performed single-cell immune profiling of lymph nodes with and without metastatic cells. Whereas no significant changes were observed for B-cell and natural killer (NK)-cell subsets, metastatic lymph nodes had a significantly increased frequency of CD8 T cells and a skewing towards an effector/memory...
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#1Anaïs Wambecke (UNICAEN: University of Caen Lower Normandy)H-Index: 3
#2Mohammad Ahmad (UNICAEN: University of Caen Lower Normandy)H-Index: 1
Last. Martin Figeac (university of lille)H-Index: 27
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Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance to chemotherapy, the 5-year survival rate in patients with OC is below 40%. We observed that UCA1, a lncRNA previously reported to play an oncogenic role in several malignancies, is overexpressed in the chemoresistant OC cell line OAW42-R compared to their chemotherapy-sensitive counterpart OAW42. Additionally, UCA1 overexpression was related to poor prognosis in two indep...
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#1Chao Fang (Sichuan University)H-Index: 6
#2Lei Dai (Sichuan University)H-Index: 13
Last. Zong-Guang Zhou (Sichuan University)H-Index: 34
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Distant metastasis is a major cause of death in patients with colorectal cancer (CRC), but the management of advanced and metastatic CRC still remains problematic due to the distinct molecular alterations during tumor progression. Tumor angiogenesis is a key step in tumor growth, invasion, and metastasis. However, the signaling pathways involved in angiogenesis are poorly understood. The results of the present study showed that secretogranin II (SCG2) was significantly downregulated in malignant...
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Top fields of study
Cancer
Molecular biology
Cancer research
Breast cancer
Medicine
Biology