Molecular Oncology
IF
6.60
Papers
1,852
Papers 1,801
1 page of 181 pages (1,801 results)
#1John Gallon (University of Basel)H-Index: 4
#2Mairene Coto-Llerena (University of Basel)H-Index: 4
Last. Salvatore Piscuoglio (University of Basel)H-Index: 36
view all 20 authors...
Hepatocellular carcinomas (HCCs) usually arise from chronic liver disease (CLD). Pre-cancerous cells in chronically inflamed environments may be 'epigenetically primed', sensitising them to oncogenic transformation. We investigated whether epigenetic priming in CLD may affect HCC outcomes by influencing the genomic and transcriptomic landscapes of HCC. Analysis of DNA methylation arrays in ten paired CLD-HCC identified 339 shared dysregulated CpG sites and 18 shared differentially methylated reg...
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#1Katrine Melvold (Oslo University Hospital)
#2Mariaserena Giliberto (Oslo University Hospital)
Last. Sigrid Strand Skånland (Oslo University Hospital)H-Index: 1
view all 11 authors...
Most patients with chronic lymphocytic leukemia (CLL) initially respond to targeted therapies, but eventually relapse and develop resistance. Novel treatment strategies are therefore needed to improve patient outcomes. Here, we performed direct drug testing on primary CLL cells and identified synergy between eight different mitogen-activated protein kinase kinase (MEK) inhibitors and the B-cell lymphoma 2 (Bcl-2) antagonist venetoclax. Drug sensitivity was independent of immunoglobulin heavy-cha...
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#1Ji Eun Yu (CBNU: Chungbuk National University)
#2In Jun Yeo (CBNU: Chungbuk National University)H-Index: 9
Last. Jin Tae Hong (CBNU: Chungbuk National University)H-Index: 51
view all 6 authors...
Chitinase 3 like 1 (Chi3L1) is associated with various biological processes, such as inflammation, tissue repair, proliferation, cell survival, invasion and extracellular matrix remodeling. Recent studies indicated that Chi3L1 is critical for cancer development and metastasis. In this study, we demonstrate that Chi3L1 serum and tissue levels were significantly increased in lung cancer patients compared to controls. We previously developed an anti-Chi3L1 humanized antibody, and here we investigat...
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#1John C. Dawson (University of Edinburgh)H-Index: 13
#2Alison F. Munro (University of Edinburgh)H-Index: 16
Last. Neil O. Carragher (University of Edinburgh)H-Index: 39
view all 9 authors...
A more comprehensive understanding of how cells respond to drug intervention, the likely immediate signalling responses and how resistance may develop within different microenvironments will help inform treatment regimes. The non-receptor tyrosine kinase SRC regulates many cellular signalling processes, and pharmacological inhibition has long been a target of cancer drug discovery projects. Here, we describe the in vitro and in vivo characterisation of the small-molecule SRC inhibitor AZD0424. W...
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#1Jun Li (Northwest University)H-Index: 4
#2Ting Zhao (Northwest University)H-Index: 5
Last. Shisheng Sun (Northwest University)H-Index: 25
view all 12 authors...
Primary liver cancer, mainly comprising hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), remains a major global health problem. Although ICC is clinically different from HCC, their molecular differences are still largely unclear. In this study, precision N-glycoproteomic analysis was performed on both ICC and HCC tumors as well as paracancer tissues to investigate their aberrant site-specific N-glycosylation. By using our newly developed glycoproteomic methods and novel ...
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#1Victor Ruiz-Rodado (NIH: National Institutes of Health)H-Index: 10
#2Tyrone Dowdy (NIH: National Institutes of Health)H-Index: 5
Last. Mioara Larion (NIH: National Institutes of Health)H-Index: 15
view all 12 authors...
Nutritional intervention is becoming more prevalent as adjuvant therapy for many cancers in view of the tumor dependence on external sources for some nutrients. However, little is known about the mechanisms that render cancer cells dependent on certain nutrients from the microenvironment. Herein, we report the dependence of glioma cells on exogenous cysteine/cystine, despite this amino acid being nonessential. Using several 13 C-tracers and analysis of cystathionine synthase and cystathioninase ...
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#1James L. GulleyH-Index: 60
#2Jeffrey SchlomH-Index: 87
Last. Aristidis Moustakas (Science for Life Laboratory)H-Index: 59
view all 9 authors...
Transforming growth factor β (TGF-β) and programmed death ligand 1 (PD-L1) initiate signaling pathways with complementary, nonredundant immunosuppressive functions in the tumor microenvironment (TME). In the TME, dysregulated TGF-β signaling suppresses antitumor immunity and promotes cancer fibrosis, epithelial-to-mesenchymal transition and angiogenesis. Meanwhile, PD-L1 expression inactivates cytotoxic T cells and restricts immunosurveillance in the TME. Anti-PD-L1 therapies have been approved ...
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#1Xiang Cheng (CSU: Central South University)H-Index: 1
#2Bin Zhang (HUST: Huazhong University of Science and Technology)H-Index: 3
Last. Xin Jin (CSU: Central South University)H-Index: 8
view all 5 authors...
Poly [ADP-ribose] polymerase (PARP) inhibitors can block DNA single-strand damage repair and subsequently increase double-stranded breaks (DSBs) by reducing the activity of the PARP1 protease and preventing the PARP1 protein from dissociating from chromatin. Tumors with the BRCA mutation are particularly sensitive to PARP inhibitors. So far, PARP inhibitors (olaparib) have been used to treat pancreatic cancer patients with BRCA mutation. However, these patients are prone to PARP-inhibitor resist...
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#1Christopher I Milton (ICR: Institute of Cancer Research)
#2Joanna Selfe (ICR: Institute of Cancer Research)H-Index: 13
Last. Janet Shipley (ICR: Institute of Cancer Research)H-Index: 52
view all 21 authors...
Rhabdomyosarcomas are aggressive pediatric soft-tissue sarcomas and include high-risk PAX3-FOXO1 fusion-gene-positive cases. Fibroblast growth factor receptor 4 (FGFR4) is known to contribute to rhabdomyosarcoma progression; here, we sought to investigate the involvement and potential for therapeutic targeting of other FGFRs in this disease. Cell-based screening of FGFR inhibitors with potential for clinical repurposing (NVP-BGJ398, nintedanib, dovitinib and ponatinib) revealed greater sensitivi...
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#1Young-Won Cho (SNU: Seoul National University)H-Index: 1
#2Dong-Wook Min (SNU: Seoul National University)H-Index: 1
Last. Tae-You Kim (SNU: Seoul National University)H-Index: 45
view all 13 authors...
Patient-derived organoids are being considered as models that can help guide personalized therapy through in vitro anti-cancer drug response evaluation. However, attempts to quantify in vitro drug responses in organoids and compare them with responses in matched patients remain inadequate. In this study, we investigated whether drug responses of organoids correlate with clinical responses of matched patients and disease progression of patients. Organoids were established from 54 patients with co...
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