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#2Beatriz Yáñez-Rivera (Consejo Nacional de Ciencia y Tecnología)H-Index: 1
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Abstract Transcriptional response regulators (TRR) are the most abundant signal transducers in prokaryotic systems that mediate intracellular changes in response to environmental signals. They are involved in a wide range of biological processes that allow bacteria to persist in particular habitats. There is strong evidence that the bacterial habitat and their lifestyle influence the size of their TRR genetic repertoire. Therefore, it would be expected that the evolution of bacterial genomes cou...
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#1Malihe Aghasizadeh (Birjand University of Medical Sciences)
#2Reza Zare-Feyzabadi (MUMS: Mashhad University of Medical Sciences)H-Index: 3
Last. Majid Ghayour-Mobarhan (MUMS: Mashhad University of Medical Sciences)H-Index: 37
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Abstract Subject: There have been a few studies on the association between the angiopoietin-like 3 (ANGPTL3) single nucleotide polymorphisms (SNPs) and the risk of cardiovascular disease (CVD). But there is no consensus about the association of ANGPTL3 haplotypes and cardiometabolic disorders. We aimed to determine the association of three variants of the ANGPTL3 gene and CVD risk factors, which included: diabetes mellitus, hypertension, obesity, metabolic syndrome, and dyslipidaemia in the MASH...
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#1Wang Xinyue (Xinjiang Agricultural University)
#2Chao Fang (University of Liège)H-Index: 1
Last. Wujun Liu (Xinjiang Agricultural University)H-Index: 2
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Abstract Fat tail is one of the most important domesticated characteristics in sheep; however its molecular mechanism is poorly understood. Here we took small-tailed F2 hybrid of wild Argali sheep and typical fat-tailed Bashby sheep as research object. First, histological analysis revealed that the mean diameter and area in tail and subcutaneous fat cells, and surface density in tail fat in Bashby sheep were significantly larger than that in F2 sheep, and surface density of fat in subcutaneous f...
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#1María Alejandra Puentes-Tellez (Pontifical Xavierian University)H-Index: 1
#2Oscar F. Sánchez (Pontifical Xavierian University)H-Index: 2
Last. Carlos Javier Alméciga Díaz (Pontifical Xavierian University)H-Index: 3
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Abstract Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease produced by the deficiency of the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme, leading to glycosaminoglycans (GAGs) accumulation. Since currently available treatments remain limited and unspecific, novel therapeutic approaches are essential for the disease treatment. In an attempt to reduce treatment limitations, gene therapy rises as a more effective and specific alternative. We present in this study t...
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#1Siyuan Zhang (Sichuan Agricultural University)H-Index: 3
#1Siyuan Zhang (FOSU: Foshan University)
Last. Ying Li (FOSU: Foshan University)H-Index: 31
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Abstract The human gut microbiota in long-living people has been characterized, however, its metabolic potential is still largely unknown in this group. In this study, the gut microbiota was assessed in 37 Chinese long-living participants (aged 90+ years) by metagenomic sequencing of stool samples. Participants were categorized into two groups, healthy long-living (n=28) and unhealthy long-living (n=9). Gut microbiota composition and function were compared among these two groups. We found that t...
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#1Run Zhong (GXUN: Guangxi University for Nationalities)
Last. Liu Hongquan (GXUN: Guangxi University for Nationalities)
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Abstract Microalgae, one of the most important classes of biomass producers, can produce exopolysaccharides similar to bacteria. The exopolysaccharide from Chlorella (CEPS) displays remarkable anticancer activity the mechanism of which remains to be elucidated. In this study, we analyzed the inhibitory effect of CEPS on the growth of HeLa cells. The results showed that CEPS inhibited the proliferation, decreased the viability, and changed the morphology of HeLa cells. Transcriptome analysis show...
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#1Doron Tolomeo (University of Bari)H-Index: 5
#2Antonio Agostini (University of Bari)H-Index: 1
Last. Clelia Tiziana Storlazzi (University of Bari)H-Index: 28
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Abstract NGS technologies and bioinformatics tools allow the rapid identification of chimeric transcripts in cancer. More than 40,000 fusions are so far reported in the literature; however, for most of them, the role in oncogenesis is still not fully understood. This is the case for fusions involving the long non-coding RNA (lncRNA) Plasmacytoma variant translocation 1 (PVT1) (8q24.21). This lncRNA displays oncogenic functions in several cancer types interacting with microRNAs and proteins, but ...
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#1Hao-Ling Cheng (ZJU: Zhejiang University)
#2Hai-Lin Dong (ZJU: Zhejiang University)H-Index: 6
Last. Zhi-Ying Wu (ZJU: Zhejiang University)H-Index: 8
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Abstract Objective To investigate whether TGM6 is a specific causative gene for spinocerebellar ataxia type 35 (SCA35). Materials and Methods The next-generation sequencing (NGS) data consisted of 47 SCA, 762 non-SCA patients and 2827 normal controls were analyzed. The allele frequencies of low frequent and deleterious TGM6 variants were compared. Functional studies were performed in five widely distributed variants (V314M, R342Q, P347L, V391M, L517W). Results Two TGM6 detrimental variants were ...
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#1Vaishnavi Sundar (VIT University)H-Index: 1
#2Anupam Dutta (VIT University)H-Index: 1
Last. Ramasamy Tamizhselvi (VIT University)H-Index: 12
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Abstract Acute Pancreatitis (AP) refers to the inflammatory state of the pancreatic mass caused by an abnormal release of digestive enzymes characterized by pancreatic acinar cell injury. It is mainly caused by gallstones, which primarily block sphincter of Oddi opening into the duodenum, heavy alcohol use, systemic diseases, etc. Stimulator of interferon genes known as STING uniquely senses the apoptotic and necrotic DNA fragments. Through the expression of TMEM173 (transmembrane protein 173) o...
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#1Parvin A. Barbhuiya (Assam University)H-Index: 4
#2Arif Uddin (Science College)H-Index: 11
Last. Supriyo Chakraborty (Assam University)H-Index: 13
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Abstract A universal phenomenon of using synonymous codons unequally in coding sequences known as codon usage bias (CUB) is observed in all forms of life. Mutation and natural selection drive CUB in many species but the relative role of evolutionary forces varies across species, genes and genomes. We studied the CUB in mitochondrial (mt) CO genes from three orders of Amphibia using bioinformatics approach as no work was reported yet. We observed that CUB of mt CO genes of Amphibians was weak acr...
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